Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy

Barbara Longobardi, Genoveffa Berardi, Claudio Fiorino, Filippo Alongi, Cesare Cozzarini, Aniko Deli, Mariangela La MacChia, Lucia Perna, Nadia Gisella Di Muzio, Riccardo Calandrino

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. Methods and materials: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ≥Grade 2 acute bowel toxicity was investigated by logistic analyses. Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN ≥ 380 cc; OR: 3.7, p = 0.017), treatment duration (

Original languageEnglish
Pages (from-to)460-464
Number of pages5
JournalRadiotherapy and Oncology
Volume101
Issue number3
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Bowel toxicity
  • IGRT
  • Prostate cancer
  • Tomotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

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