Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy

Barbara Longobardi; Genoveffa Berardi; Claudio Fiorino; Filippo Alongi; Cesare Cozzarini; Aniko Deli; Mariangela La MacChia; Lucia Perna; Nadia Gisella Di Muzio; Riccardo Calandrino

doi:10.1016/j.radonc.2011.07.014

Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy

Barbara Longobardi, Genoveffa Berardi, Claudio Fiorino, Filippo Alongi, Cesare Cozzarini, Aniko Deli, Mariangela La MacChia, Lucia Perna, Nadia Gisella Di Muzio, Riccardo Calandrino

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. Methods and materials: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ≥Grade 2 acute bowel toxicity was investigated by logistic analyses. Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN ≥ 380 cc; OR: 3.7, p = 0.017), treatment duration (

Original language	English
Pages (from-to)	460-464
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2011.07.014
Publication status	Published - Dec 2011

Keywords

Bowel toxicity
IGRT
Prostate cancer
Tomotherapy

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Hematology

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Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy. / Longobardi, Barbara; Berardi, Genoveffa; Fiorino, Claudio; Alongi, Filippo; Cozzarini, Cesare; Deli, Aniko; La MacChia, Mariangela; Perna, Lucia; Di Muzio, Nadia Gisella ; Calandrino, Riccardo.

In: Radiotherapy and Oncology, Vol. 101, No. 3, 12.2011, p. 460-464.

Research output: Contribution to journal › Article › peer-review

Longobardi, Barbara ; Berardi, Genoveffa ; Fiorino, Claudio ; Alongi, Filippo ; Cozzarini, Cesare ; Deli, Aniko ; La MacChia, Mariangela ; Perna, Lucia ; Di Muzio, Nadia Gisella ; Calandrino, Riccardo. / Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy. In: Radiotherapy and Oncology. 2011 ; Vol. 101, No. 3. pp. 460-464.

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abstract = "Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. Methods and materials: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ≥Grade 2 acute bowel toxicity was investigated by logistic analyses. Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN ≥ 380 cc; OR: 3.7, p = 0.017), treatment duration (",

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AU - Deli, Aniko

AU - La MacChia, Mariangela

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