Abstract
Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. Methods and materials: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ≥Grade 2 acute bowel toxicity was investigated by logistic analyses. Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN ≥ 380 cc; OR: 3.7, p = 0.017), treatment duration (
| Original language | English |
|---|---|
| Pages (from-to) | 460-464 |
| Number of pages | 5 |
| Journal | Radiotherapy and Oncology |
| Volume | 101 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 2011 |
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Keywords
- Bowel toxicity
- IGRT
- Prostate cancer
- Tomotherapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Hematology
Cite this
Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy. / Longobardi, Barbara; Berardi, Genoveffa; Fiorino, Claudio; Alongi, Filippo; Cozzarini, Cesare; Deli, Aniko; La MacChia, Mariangela; Perna, Lucia; Di Muzio, Nadia Gisella; Calandrino, Riccardo.
In: Radiotherapy and Oncology, Vol. 101, No. 3, 12.2011, p. 460-464.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anatomical and clinical predictors of acute bowel toxicity in whole pelvis irradiation for prostate cancer with Tomotherapy
AU - Longobardi, Barbara
AU - Berardi, Genoveffa
AU - Fiorino, Claudio
AU - Alongi, Filippo
AU - Cozzarini, Cesare
AU - Deli, Aniko
AU - La MacChia, Mariangela
AU - Perna, Lucia
AU - Di Muzio, Nadia Gisella
AU - Calandrino, Riccardo
PY - 2011/12
Y1 - 2011/12
N2 - Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. Methods and materials: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ≥Grade 2 acute bowel toxicity was investigated by logistic analyses. Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN ≥ 380 cc; OR: 3.7, p = 0.017), treatment duration (
AB - Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed. Methods and materials: In the period March 2005-April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8 Gy/28 fractions while concomitantly delivering 65.5-74.2 Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ≥Grade 2 acute bowel toxicity was investigated by logistic analyses. Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN ≥ 380 cc; OR: 3.7, p = 0.017), treatment duration (
KW - Bowel toxicity
KW - IGRT
KW - Prostate cancer
KW - Tomotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=81855165038&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2011.07.014
DO - 10.1016/j.radonc.2011.07.014
M3 - Article
C2 - 21864924
AN - SCOPUS:81855165038
VL - 101
SP - 460
EP - 464
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - 3
ER -