Anatomical and functional retinal changes in multiple sclerosis

G. Cennamo, M. R. Romano, E. C. Vecchio, C. Minervino, C. Della Guardia, N. Velotti, A. Carotenuto, S. Montella, G. Orefice, G. Cennamo

Research output: Contribution to journalArticlepeer-review


Aims: The aims of this study was to report anatomical changes of the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) thickness, and macular volume in patients with multiple sclerosis (MS). We also investigated the correlation between anatomical and functional changes in terms of visual acuity and macular sensitivity investigated and visual fields. Methods: Prospective comparative study included 105 eyes of 53 consecutive patients. The patients were divided into two groups: group A included 56 eyes of 28 patients with diagnosis of MS; group B involved 49 eyes of 25 healthy patients. The examination included Goldmann tonometry, biomicroscopic and fundus oculi examination, retinography, GCC examination, circumpapillary RNFL (cpRNFL), and macular volume. The functional test included measurement of best-corrected visual acuity (BCVA), visual field, and MP. Results: MS group showed a significant reduced GCC, cpRNFL, macular volume, BCVA, visual field, and macular sensitivity compared with the control group (P2=0.59, P2=0.48, P2=0.25, P2=0.43, P

Original languageEnglish
Pages (from-to)456-462
Number of pages7
JournalEye (London, England)
Issue number3
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Ophthalmology


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