Anatomical correlates of visual and tactile extinction in humans: A clinical CT scan study

Giuseppe Vallar, Maria Luisa Rusconi, Lorenzo Bignamini, Giuliano Geminiani, Daniela Perani

Research output: Contribution to journalArticlepeer-review

Abstract

The anatomical correlates of tactile and visual extinction with double simultaneous stimulation were investigated in a series of 159 patients with right brain damage caused by stroke. Forty six patients showed extinction (22 tactile, 14 visual, 10 tactile and visual). Over 50% of the patients with extinction had deep lesions, which were found in about 25% of the patients with visuospatial neglect not associated with extinction. In the patients with extinction and cortico-subcortical damage the paraventricular occipital white matter and the dorsolateral frontal cortex were most often involved. By contrast, when neglect was also present, the lesions clustered in the inferior parietal lobule. These data suggest, from an anatomical perspective, that partly different neural mechanisms may underlie neglect and extinction. The comparatively high frequency of subcortical lesions involving the ascending pathways may be a neural correlate of a sensory component of extinction.

Original languageEnglish
Pages (from-to)464-470
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume57
Issue number4
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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