Anatomical functional changes in a patient presenting a complex malformation of cortical development

Valentina Calistri, Delia Lenzi, Francesca Gilio, Carlo Di Bonaventura, Maurizio Inghilleri, Caterina Mainero, Patrizia Pantano

Research output: Contribution to journalArticlepeer-review


The authors describe a case of right fronto-parietal micropoligyria associated with small schizencephaly clefts and the presence of a frontal open-lip schizencephaly with corpus callosum agenesis. A functional magnetic resonance imaging (fMRI) study was performed to evaluate the possible reorganization of cortical functions in a patient presenting a complex malformation pattern and to investigate which cortical areas were activated during left finger movements. An fMRI study was performed during the execution of a repetitive index finger-to-thumb opposition movement with the right hand and the left hand in 2 separate sessions. Movement of the right hand induced a normal motor activation pattern involving the contralateral left sensory-motor cortex. Movement of the left hand produced significant activation of brain cortex. This fMRI study highlights the compensatory role of the ipsilateral cortical pathways in hand movements in the case of a complex brain malformation that involves the main motor activation areas.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalJournal of Neuroimaging
Issue number4
Publication statusPublished - Oct 2004


  • Corpus callosum agenesis
  • Functional magnetic resonance imaging (fMRI)
  • Motor activity
  • Schizencephaly

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology


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