Anatomical identification of active contacts in subthalamic deep brain stimulation

Francesco Vergani, Andrea Landi, Angelo Antonini, Michele Parolin, Roberto Cilia, Marco Grimaldi, Carlo Ferrarese, Sergio M. Gaini, Erik P. Sganzerla

Research output: Contribution to journalArticle

Abstract

Background: Subthalamic Deep Brain Stimulation is a valid surgical procedure for the treatment of idiopathic PD, although its precise mechanism of action is still unclear; moreover, there are no conclusive data about the functional anatomy of the human subthalamic region. Identifying the location of active contacts for StnDBS can yield interesting insights on the mechanisms of action of DBS and the different role played by the anatomical structures of the subthalamic region. Methods: Twenty-five patients operated on for bilateral StnDBS were considered. During the surgical procedure, a complete intraoperative neurophysiological study was obtained by means of semimicrorecordings and stimulations. After surgery, an MRI study confirmed the position of the electrodes; MR images were subsequently superimposed onto a stereotactic atlas by using a dedicated workstation. The coordinates relative to the tip of the electrodes and active contacts were then calculated. Results: Most of the electrode tips are located inside the subthalamus or immediately ventrally to it. Of the active contacts used for chronic stimulation, 96.5% are located in a well-defined anatomical region, which includes subthalamus, zona incerta, and FF. Conclusions: Our findings seem to suggest that other structures beyond the subthalamus itself play a clinical role in symptoms control after DBS for PD.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalSurgical Neurology
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2007

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Subthalamus
Deep Brain Stimulation
Electrodes
Atlases
Anatomy
Therapeutics

Keywords

  • Active contact
  • Deep brain stimulation
  • Functional neurosurgery
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Vergani, F., Landi, A., Antonini, A., Parolin, M., Cilia, R., Grimaldi, M., ... Sganzerla, E. P. (2007). Anatomical identification of active contacts in subthalamic deep brain stimulation. Surgical Neurology, 67(2), 140-146. https://doi.org/10.1016/j.surneu.2006.06.054

Anatomical identification of active contacts in subthalamic deep brain stimulation. / Vergani, Francesco; Landi, Andrea; Antonini, Angelo; Parolin, Michele; Cilia, Roberto; Grimaldi, Marco; Ferrarese, Carlo; Gaini, Sergio M.; Sganzerla, Erik P.

In: Surgical Neurology, Vol. 67, No. 2, 02.2007, p. 140-146.

Research output: Contribution to journalArticle

Vergani, F, Landi, A, Antonini, A, Parolin, M, Cilia, R, Grimaldi, M, Ferrarese, C, Gaini, SM & Sganzerla, EP 2007, 'Anatomical identification of active contacts in subthalamic deep brain stimulation', Surgical Neurology, vol. 67, no. 2, pp. 140-146. https://doi.org/10.1016/j.surneu.2006.06.054
Vergani F, Landi A, Antonini A, Parolin M, Cilia R, Grimaldi M et al. Anatomical identification of active contacts in subthalamic deep brain stimulation. Surgical Neurology. 2007 Feb;67(2):140-146. https://doi.org/10.1016/j.surneu.2006.06.054
Vergani, Francesco ; Landi, Andrea ; Antonini, Angelo ; Parolin, Michele ; Cilia, Roberto ; Grimaldi, Marco ; Ferrarese, Carlo ; Gaini, Sergio M. ; Sganzerla, Erik P. / Anatomical identification of active contacts in subthalamic deep brain stimulation. In: Surgical Neurology. 2007 ; Vol. 67, No. 2. pp. 140-146.
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