(-)- and (±)-moprolol in the treatment of mild and moderate hypertension. A double-blind randomized trial

M. Volpe, B. Trimarco, A. M. Veniero

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical efficacy and the tolerability of (-)-moprolol and of the racemic derivative (±)-moprolol were studied in twenty mild or moderate hypertensive patients in a double-blind cross-over trial. Both the compounds significantly reduced blood pressure, but only (-)-moprolol reduced heart rate. (-)-Moprolol induced a reduction in cardiac output, whereas (±)-moprolol did not change cardiac output, but significantly reduced total peripheral resistance. Both the drugs improved significantly the tolerance to exercise. (-)-Moprolol did not induce any significant side effect, whereas (±)-moprolol caused headache or dizziness in five patients.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalCurrent Therapeutic Research
Volume35
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)

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