Androgen receptor as a biomarker of oral squamous cell carcinoma progression risk

Cedna Tomasovic-Loncaric, Aleksandra Fucic, Ana Andabak, Matej Andabak, Marcello Ceppi, Marco Bruzzone, Danko Vrdoljak, Vanja Vucicevic-Boras

Research output: Contribution to journalArticle

Abstract

Background/Aim: Oral squamous cell carcinoma (OSCC) is a cancer with poor prognosis due to therapy resistance, locoregional recurrences, and distant metastases. There is on increased interest in profiling the androgen receptor (AR) in cancer biology. The aim of this study was to compare AR and Ki-67 levels in the neoplastic epithelium and stroma between non-metastatic and metastatic stages of OSCC. Patients and Methods: Tissue specimens of 101 non-metastatic and 95 metastatic OSCC patients were analyzed by immunohistochemistry. Results: More than 20% of AR-positive cytoplasmic staining of OSCC epithelium was significantly associated with nuclear AR levels in the epithelium and increased AR levels in the stroma. In metastatic OSCC patients, Ki-67 was significantly higher than in non-metastatic OSCC patients. Conclusion: More than 20% of AR-positive cytoplasmic staining in neoplastic OSSC epithelium is a significant predictor of OSCC progression risk.

Original languageEnglish
Pages (from-to)4285-4289
Number of pages5
JournalAnticancer Research
Volume39
Issue number8
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Androgen receptor
  • Biomarker
  • Ki67
  • Metastasis
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Tomasovic-Loncaric, C., Fucic, A., Andabak, A., Andabak, M., Ceppi, M., Bruzzone, M., Vrdoljak, D., & Vucicevic-Boras, V. (2019). Androgen receptor as a biomarker of oral squamous cell carcinoma progression risk. Anticancer Research, 39(8), 4285-4289. https://doi.org/10.21873/anticanres.13593