Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon

G. Sica, G. Dell'Acqua, F. Iacopino, A. Fattorossi, P. Marchetti, T. H. van der Kwast, M. Pavone-Macaluso

Research output: Contribution to journalArticle

Abstract

Androgen recptors are expressed at a low level in the cell line PC-3, which does not respond to either androgens or antiandrogens. If these cells are exposed to natural beta-interferon (β-IFN) a reduction in cell growth and an increase in androgen receptors, evaluated by both biochemical and immunocytochemical techniques, occur. This increase seems not to be related to a selective block of PC-3 in any phase of the cell cycle. Pretreatment with β-IFN determines in PC-3 cells a partial responsiveness to the androgen dihydrotestosterone as reflected by the increase in cell number. Moreover, the antiandrogen hydroxyflutamide shows agonistic properties by increasing the cell number of PC-3 cells pre-exposed to β-IFN. When the antiandrogen is tested in combination with interferon, it produces a reduction in the β-IFN-induced inhibition of cell growth. It is not known whether these unexpected effects are due to the increase in androgen receptors or to other mechanisms.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalUrological Research
Volume22
Issue number1
DOIs
Publication statusPublished - 1991

Fingerprint

Interferon-beta
Androgen Receptors
Prostatic Neoplasms
Androgen Antagonists
Hormones
Cell Line
Androgens
Cell Count
Dihydrotestosterone
Growth
Interferons
Cell Cycle

Keywords

  • Androgen receptors
  • Hormone sensitivity
  • Hydroxyflutamide
  • Interferon
  • Prostatic cancer

ASJC Scopus subject areas

  • Urology

Cite this

Sica, G., Dell'Acqua, G., Iacopino, F., Fattorossi, A., Marchetti, P., van der Kwast, T. H., & Pavone-Macaluso, M. (1991). Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon. Urological Research, 22(1), 33-38. https://doi.org/10.1007/BF00431546

Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon. / Sica, G.; Dell'Acqua, G.; Iacopino, F.; Fattorossi, A.; Marchetti, P.; van der Kwast, T. H.; Pavone-Macaluso, M.

In: Urological Research, Vol. 22, No. 1, 1991, p. 33-38.

Research output: Contribution to journalArticle

Sica, G, Dell'Acqua, G, Iacopino, F, Fattorossi, A, Marchetti, P, van der Kwast, TH & Pavone-Macaluso, M 1991, 'Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon', Urological Research, vol. 22, no. 1, pp. 33-38. https://doi.org/10.1007/BF00431546
Sica, G. ; Dell'Acqua, G. ; Iacopino, F. ; Fattorossi, A. ; Marchetti, P. ; van der Kwast, T. H. ; Pavone-Macaluso, M. / Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon. In: Urological Research. 1991 ; Vol. 22, No. 1. pp. 33-38.
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