Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon

G. Sica, G. Dell'Acqua, F. Iacopino, A. Fattorossi, P. Marchetti, T. H. van der Kwast, M. Pavone-Macaluso

Research output: Contribution to journalArticlepeer-review

Abstract

Androgen recptors are expressed at a low level in the cell line PC-3, which does not respond to either androgens or antiandrogens. If these cells are exposed to natural beta-interferon (β-IFN) a reduction in cell growth and an increase in androgen receptors, evaluated by both biochemical and immunocytochemical techniques, occur. This increase seems not to be related to a selective block of PC-3 in any phase of the cell cycle. Pretreatment with β-IFN determines in PC-3 cells a partial responsiveness to the androgen dihydrotestosterone as reflected by the increase in cell number. Moreover, the antiandrogen hydroxyflutamide shows agonistic properties by increasing the cell number of PC-3 cells pre-exposed to β-IFN. When the antiandrogen is tested in combination with interferon, it produces a reduction in the β-IFN-induced inhibition of cell growth. It is not known whether these unexpected effects are due to the increase in androgen receptors or to other mechanisms.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalUrological Research
Volume22
Issue number1
DOIs
Publication statusPublished - 1991

Keywords

  • Androgen receptors
  • Hormone sensitivity
  • Hydroxyflutamide
  • Interferon
  • Prostatic cancer

ASJC Scopus subject areas

  • Urology

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