Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers

Giorgio Secreto, Elisabetta Venturelli, Elisabetta Meneghini, Maria Luisa Carcangiu, Biagio Paolini, Roberto Agresti, Cristina Pellitteri, Franco Berrino, Massimo Gion, Patrizia Cogliati, Giuseppina Saragò, Andrea Micheli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Androgen receptors (AR) are frequently expressed in breast cancers, but their implication in cancer growth is still controversial. In the present study, we further investigated the role of the androgen/AR pathway in breast cancer development.Methods: AR expression was evaluated by immunochemistry in a cohort of 528 postmenopausal breast cancer patients previously examined for the association of serum testosterone levels with patient and tumor characteristics. AR expression was classified according to the percentage of stained cells: AR-absent (0%) and AR-poorly (1%-30%), AR-moderately (>30%-60%), and AR-highly (>60%) positive.Results: Statistical analysis was performed in 451 patients who experienced natural menopause. AR-high expression was significantly related with low histologic grade and estrogen receptor (ER)- and progesterone receptor (PR)-positive status (P trend

Original languageEnglish
Article number599
JournalBMC Cancer
Volume12
DOIs
Publication statusPublished - Dec 14 2012

Keywords

  • Androgen receptors
  • Androgens
  • Postmenopausal breast cancer
  • Testosterone levels

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Fingerprint

Dive into the research topics of 'Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers'. Together they form a unique fingerprint.

Cite this