TY - JOUR
T1 - Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers
AU - Secreto, Giorgio
AU - Venturelli, Elisabetta
AU - Meneghini, Elisabetta
AU - Carcangiu, Maria Luisa
AU - Paolini, Biagio
AU - Agresti, Roberto
AU - Pellitteri, Cristina
AU - Berrino, Franco
AU - Gion, Massimo
AU - Cogliati, Patrizia
AU - Saragò, Giuseppina
AU - Micheli, Andrea
PY - 2012/12/14
Y1 - 2012/12/14
N2 - Background: Androgen receptors (AR) are frequently expressed in breast cancers, but their implication in cancer growth is still controversial. In the present study, we further investigated the role of the androgen/AR pathway in breast cancer development.Methods: AR expression was evaluated by immunochemistry in a cohort of 528 postmenopausal breast cancer patients previously examined for the association of serum testosterone levels with patient and tumor characteristics. AR expression was classified according to the percentage of stained cells: AR-absent (0%) and AR-poorly (1%-30%), AR-moderately (>30%-60%), and AR-highly (>60%) positive.Results: Statistical analysis was performed in 451 patients who experienced natural menopause. AR-high expression was significantly related with low histologic grade and estrogen receptor (ER)- and progesterone receptor (PR)-positive status (P trend
AB - Background: Androgen receptors (AR) are frequently expressed in breast cancers, but their implication in cancer growth is still controversial. In the present study, we further investigated the role of the androgen/AR pathway in breast cancer development.Methods: AR expression was evaluated by immunochemistry in a cohort of 528 postmenopausal breast cancer patients previously examined for the association of serum testosterone levels with patient and tumor characteristics. AR expression was classified according to the percentage of stained cells: AR-absent (0%) and AR-poorly (1%-30%), AR-moderately (>30%-60%), and AR-highly (>60%) positive.Results: Statistical analysis was performed in 451 patients who experienced natural menopause. AR-high expression was significantly related with low histologic grade and estrogen receptor (ER)- and progesterone receptor (PR)-positive status (P trend
KW - Androgen receptors
KW - Androgens
KW - Postmenopausal breast cancer
KW - Testosterone levels
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U2 - 10.1186/1471-2407-12-599
DO - 10.1186/1471-2407-12-599
M3 - Article
C2 - 23241075
AN - SCOPUS:84870861698
VL - 12
JO - BMC Cancer
JF - BMC Cancer
SN - 1471-2407
M1 - 599
ER -