TY - JOUR
T1 - Androgens and adipose tissue in males
T2 - A complex and reciprocal interplay
AU - Mammi, Caterina
AU - Calanchini, Matilde
AU - Antelmi, Antonella
AU - Cinti, Francesca
AU - Rosano, Giuseppe M C
AU - Lenzi, Andrea
AU - Caprio, Massimiliano
AU - Fabbri, Andrea
PY - 2012
Y1 - 2012
N2 - Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a "hallmark" of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost.
AB - Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a "hallmark" of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost.
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U2 - 10.1155/2012/789653
DO - 10.1155/2012/789653
M3 - Article
C2 - 22235202
AN - SCOPUS:84855568280
VL - 2012
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
SN - 1687-8337
M1 - 789653
ER -