Androgens and adipose tissue in males: A complex and reciprocal interplay

Caterina Mammi, Matilde Calanchini, Antonella Antelmi, Francesca Cinti, Giuseppe M C Rosano, Andrea Lenzi, Massimiliano Caprio, Andrea Fabbri

Research output: Contribution to journalArticlepeer-review


Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a "hallmark" of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost.

Original languageEnglish
Article number789653
JournalInternational Journal of Endocrinology
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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