TY - JOUR
T1 - Androgens and penile erection
T2 - Evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction
AU - Aversa, A.
AU - Isidori, A. M.
AU - De Martino, M. U.
AU - Caprio, M.
AU - Fabbrini, E.
AU - Rocchietti-March, M.
AU - Frajese, G.
AU - Fabbri, A.
PY - 2000
Y1 - 2000
N2 - OBJECTIVE: Androgens are essential in the maintenance of nitric oxide-mediated erectile activity in the rat. The objective of the present study was to investigate the role of androgens in regulating trabecular smooth muscle relaxation in the corpus cavernosum in response to vasoactive challenge in men with erectile dysfunction (ED). DESIGN: Retrospective, double-blind correlation analyses. PATIENTS: Fifty-two impotent patients without confounding risk factors for ED were obtained from a total of 250 undergoing diagnostic evaluation. MEASUREMENTS: All patients had dynamic colour duplex ultrasound (D-CDU) and hormonal evaluation for LH, total and free testosterone, SHBG and oestradiol. RESULTS: Based upon D-CDU results patients were diagnosed as having arteriogenic (AR, n= 18; mean age 51) or corporeal venocclusive (CVO, n= 13; mean age 49) ED; in other patients (n = 21, mean age 43) a diagnosis of psychogenic (P)-ED was made by comprehensive psychogenic testing and confirmed by normal D-CDU results. AR and CVO patients had altered compliance of cavernous arteries recorded by D-CDU [20-25% lower resistive index (RI) than patients with psychogenic ED], and lower free testosterone (FT) levels than psychogenic patients [42·3 ± 3·5 SE and 49·3 ± 5·2 vs. 75·2 ± 7·6pmol/l, respectively; P
AB - OBJECTIVE: Androgens are essential in the maintenance of nitric oxide-mediated erectile activity in the rat. The objective of the present study was to investigate the role of androgens in regulating trabecular smooth muscle relaxation in the corpus cavernosum in response to vasoactive challenge in men with erectile dysfunction (ED). DESIGN: Retrospective, double-blind correlation analyses. PATIENTS: Fifty-two impotent patients without confounding risk factors for ED were obtained from a total of 250 undergoing diagnostic evaluation. MEASUREMENTS: All patients had dynamic colour duplex ultrasound (D-CDU) and hormonal evaluation for LH, total and free testosterone, SHBG and oestradiol. RESULTS: Based upon D-CDU results patients were diagnosed as having arteriogenic (AR, n= 18; mean age 51) or corporeal venocclusive (CVO, n= 13; mean age 49) ED; in other patients (n = 21, mean age 43) a diagnosis of psychogenic (P)-ED was made by comprehensive psychogenic testing and confirmed by normal D-CDU results. AR and CVO patients had altered compliance of cavernous arteries recorded by D-CDU [20-25% lower resistive index (RI) than patients with psychogenic ED], and lower free testosterone (FT) levels than psychogenic patients [42·3 ± 3·5 SE and 49·3 ± 5·2 vs. 75·2 ± 7·6pmol/l, respectively; P
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U2 - 10.1046/j.1365-2265.2000.01118.x
DO - 10.1046/j.1365-2265.2000.01118.x
M3 - Article
C2 - 11012578
AN - SCOPUS:0033792530
VL - 53
SP - 517
EP - 522
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 4
ER -