Andrographis paniculata shows anti-nociceptive effects in an animal model of sensory hypersensitivity associated with migraine

Rosaria Greco, Francesca Siani, Chiara Demartini, Annamaria Zanaboni, Giuseppe Nappi, Sergio Davinelli, Giovanni Scapagnini, Cristina Tassorelli

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of nitroglycerin (NTG) to rats induces a hyperalgesic condition and neuronal activation of central structures involved in migraine pain. In order to identify therapeutic strategies for migraine pain, we evaluated the anti-nociceptive activity of Andrographis Paniculata (AP), a herbaceous plant, in the hyperalgesia induced by NTG administration in the formalin test. We also analyzed mRNA expression of cytokines in specific brain areas after AP treatment. Male Sprague-Dawley rats were pre-treated with AP extract 30 minutes before NTG or vehicle injection. The data show that AP extract significantly reduced NTG-induced hyperalgesia in phase II of the test, 4 hours after NTG injection. In addition, AP extract reduced IL-6 mRNA expression in the medulla and mesencephalon and also mRNA levels of TNF- alpha in the mesencephalic region. These findings suggest that AP extract may be a potential therapeutic approach in the treatment of general pain, and possibly of migraine.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalFunctional Neurology
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Andrographis paniculata
  • Cytokines
  • Formalin test
  • Migraine
  • Nitroglycerin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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