Andropausal syndrome in men with systolic heart failure

Michał Tkaczyszyn, Katarzyna Nega, Monika Łopuszańska, Alicja Szklarska, Marek Medraś, Beata Ponikowska, Stephan Von Haehling, Wolfram Doehner, Waldemar Banasiak, Stefan D. Anker, Piotr Ponikowski, Ewa A. Jankowska

Research output: Contribution to journalArticle

Abstract

Introduction Andropausal syndrome (AS) is an element of male aging, being associated with the age-related decline in circulating androgens. Objectives We investigated the prevalence of AS, the severity of andropausal symptoms, and their clinical and hormonal determinants in men with heart failure (HF) and healthy peers. Patients and methods We examined 232 men with systolic HF aged from 40 to 80 years (New York Heart Association [NYHA] class I/II/III-IV: 17%/54%/29%, left ventricular ejection fraction: 30% ±8%) and 362 healthy peers. The severity of 17 andropausal symptoms were assessed using the Aging Males' Symptoms Rating Scale. Results In men with HF aged from 40 to 59 years, the prevalence of AS and the severity of andropausal symptoms were greater than in healthy peers (28% vs. 7%; 40 ±14 vs. 35 ±10 points; both P 0.1). In men with HF aged from 40 to 59 years, advanced NYHA class, low hemoglobin, increased platelet number, and low serum dehydroepiandrosterone sulphate were independently associated with the greater prevalence of AS (all P

Original languageEnglish
Pages (from-to)156-169
Number of pages14
JournalPolskie Archiwum Medycyny Wewnetrznej
Volume123
Issue number4
Publication statusPublished - 2013

Keywords

  • Anabolic hormone deficiency
  • Andropausal syndrome
  • Heart failure
  • Male aging
  • Testosterone

ASJC Scopus subject areas

  • Internal Medicine

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