TY - JOUR
T1 - Andropausal syndrome in men with systolic heart failure
AU - Tkaczyszyn, Michał
AU - Nega, Katarzyna
AU - Łopuszańska, Monika
AU - Szklarska, Alicja
AU - Medraś, Marek
AU - Ponikowska, Beata
AU - Von Haehling, Stephan
AU - Doehner, Wolfram
AU - Banasiak, Waldemar
AU - Anker, Stefan D.
AU - Ponikowski, Piotr
AU - Jankowska, Ewa A.
PY - 2013
Y1 - 2013
N2 - Introduction Andropausal syndrome (AS) is an element of male aging, being associated with the age-related decline in circulating androgens. Objectives We investigated the prevalence of AS, the severity of andropausal symptoms, and their clinical and hormonal determinants in men with heart failure (HF) and healthy peers. Patients and methods We examined 232 men with systolic HF aged from 40 to 80 years (New York Heart Association [NYHA] class I/II/III-IV: 17%/54%/29%, left ventricular ejection fraction: 30% ±8%) and 362 healthy peers. The severity of 17 andropausal symptoms were assessed using the Aging Males' Symptoms Rating Scale. Results In men with HF aged from 40 to 59 years, the prevalence of AS and the severity of andropausal symptoms were greater than in healthy peers (28% vs. 7%; 40 ±14 vs. 35 ±10 points; both P 0.1). In men with HF aged from 40 to 59 years, advanced NYHA class, low hemoglobin, increased platelet number, and low serum dehydroepiandrosterone sulphate were independently associated with the greater prevalence of AS (all P
AB - Introduction Andropausal syndrome (AS) is an element of male aging, being associated with the age-related decline in circulating androgens. Objectives We investigated the prevalence of AS, the severity of andropausal symptoms, and their clinical and hormonal determinants in men with heart failure (HF) and healthy peers. Patients and methods We examined 232 men with systolic HF aged from 40 to 80 years (New York Heart Association [NYHA] class I/II/III-IV: 17%/54%/29%, left ventricular ejection fraction: 30% ±8%) and 362 healthy peers. The severity of 17 andropausal symptoms were assessed using the Aging Males' Symptoms Rating Scale. Results In men with HF aged from 40 to 59 years, the prevalence of AS and the severity of andropausal symptoms were greater than in healthy peers (28% vs. 7%; 40 ±14 vs. 35 ±10 points; both P 0.1). In men with HF aged from 40 to 59 years, advanced NYHA class, low hemoglobin, increased platelet number, and low serum dehydroepiandrosterone sulphate were independently associated with the greater prevalence of AS (all P
KW - Anabolic hormone deficiency
KW - Andropausal syndrome
KW - Heart failure
KW - Male aging
KW - Testosterone
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M3 - Article
C2 - 23449158
AN - SCOPUS:84879625689
VL - 123
SP - 156
EP - 169
JO - Polskie Archiwum Medycyny Wewnetrznej
JF - Polskie Archiwum Medycyny Wewnetrznej
SN - 0032-3772
IS - 4
ER -