Anemia and inflammation in COPD

Matthias John, Soeren Hoernig, Wolfram Doehner, Darlington D. Okonko, Christian Witt, Stefan D. Anker

Research output: Contribution to journalArticlepeer-review


Background: Anemia in patients with COPD and its pathophysiology is an understudied issue. Methods: In a group of 101 COPD patients (FEV1 percentage of predicted, 37 ± 2% [mean ± SEM]; mean age, 61 ± 1 years; 35% female gender), the prevalence of anemia and its relationship to body mass and weight loss, inflammatory parameters, and erythropoietin levels was determined. Data were compared to a control group (healthy persons with matched age) in order to identify potential factors that may influence the development of anemia in patients with COPD. Results: Anemia was diagnosed in 13 patients (hemoglobin levels <13.5 mg/dL in male patients and <12.0 mg/dL in female patients), which represents a prevalence of 13%. Anemic COPD patients showed elevated erythropoietin levels (41.8 ± 25.4 U/L vs 16.3 ± 2.9 U/L) and an increased inflammatory response compared to nonanemic patients. A significant inverse correlation of hemoglobin vs erythropoietin (r = -0.84, p <0.01) was observed in anemic COPD patients, but not in the nonanemic group. Conclusion: Anemic COPD patients show high erythropoietin levels, which may indicate presence of erythropoietin resistance. The latter may be mediated through inflammatory mechanisms, which is typical for anemia of chronic illness.

Original languageEnglish
Pages (from-to)825-829
Number of pages5
Issue number3
Publication statusPublished - Mar 2005


  • Anemia
  • COPD
  • Inflammation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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