Anemia in young patients with ischaemic stroke

L. Kellert, M. Kloss, A. Pezzini, T. M. Metso, A. J. Metso, S. Debette, D. Leys, V. Caso, V. Thijs, A. Bersano, E. Touzé, T. Tatlisumak, H. Gensicke, P. A. Lyrer, J. Bösel, S. T. Engelter, C. Grond-Ginsbach

Research output: Contribution to journalArticle

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Abstract

Background and purpose: To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non-CeAD-IS patients). Methods: The study sample comprised all patients from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) study without pre-existing disability and with documentation of stroke severity and hemoglobin (Hb) concentration on admission. Anemia was classified as mild (Hb <12 g/dl in women and Hb <13 g/dl in men) or moderate to severe (Hb <10 g/dl in women and Hb <11 g/dl in men). Stroke severity on admission was assessed with the National Institutes of Health Stroke Scale (NIHSS). Outcome after 3 months was assessed with the modified Rankin Scale (mRS-3mo). Unfavorable outcome was defined as mRS-3mo ≥ 3. Results: Amongst 1206 study patients (691 CeAD and 515 non-CeAD), 87 (7.2%) had anemia, which was moderate to severe in 18 (1.5%) patients. Anemia was associated with female sex in both study samples, but no further associations with risk factors or comorbidities were observed. In CeAD patients, anemia was associated with occurrence of stroke (P = 0.042). In both study samples, anemic patients had more severe strokes (CeAD, P = 0.023; non-CeAD, P = 0.005). Functional outcome was not associated with anemia in general, but moderate to severe anemia was significantly associated with unfavorable outcome (P = 0.004). Conclusion: Anemia on admission was associated with stroke in CeAD patients and with more severe strokes in both study samples. Moderate to severe anemia may predict unfavorable outcome.

Original languageEnglish
Pages (from-to)948-953
Number of pages6
JournalEuropean Journal of Neurology
Volume22
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Anemia
Stroke
Dissection
Arteries
Hemoglobins
National Institutes of Health (U.S.)
Documentation
Comorbidity

Keywords

  • Anemia
  • Cervical artery dissection
  • Ischaemic stroke
  • Stroke severity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Kellert, L., Kloss, M., Pezzini, A., Metso, T. M., Metso, A. J., Debette, S., ... Grond-Ginsbach, C. (2015). Anemia in young patients with ischaemic stroke. European Journal of Neurology, 22(6), 948-953. https://doi.org/10.1111/ene.12687

Anemia in young patients with ischaemic stroke. / Kellert, L.; Kloss, M.; Pezzini, A.; Metso, T. M.; Metso, A. J.; Debette, S.; Leys, D.; Caso, V.; Thijs, V.; Bersano, A.; Touzé, E.; Tatlisumak, T.; Gensicke, H.; Lyrer, P. A.; Bösel, J.; Engelter, S. T.; Grond-Ginsbach, C.

In: European Journal of Neurology, Vol. 22, No. 6, 01.06.2015, p. 948-953.

Research output: Contribution to journalArticle

Kellert, L, Kloss, M, Pezzini, A, Metso, TM, Metso, AJ, Debette, S, Leys, D, Caso, V, Thijs, V, Bersano, A, Touzé, E, Tatlisumak, T, Gensicke, H, Lyrer, PA, Bösel, J, Engelter, ST & Grond-Ginsbach, C 2015, 'Anemia in young patients with ischaemic stroke', European Journal of Neurology, vol. 22, no. 6, pp. 948-953. https://doi.org/10.1111/ene.12687
Kellert L, Kloss M, Pezzini A, Metso TM, Metso AJ, Debette S et al. Anemia in young patients with ischaemic stroke. European Journal of Neurology. 2015 Jun 1;22(6):948-953. https://doi.org/10.1111/ene.12687
Kellert, L. ; Kloss, M. ; Pezzini, A. ; Metso, T. M. ; Metso, A. J. ; Debette, S. ; Leys, D. ; Caso, V. ; Thijs, V. ; Bersano, A. ; Touzé, E. ; Tatlisumak, T. ; Gensicke, H. ; Lyrer, P. A. ; Bösel, J. ; Engelter, S. T. ; Grond-Ginsbach, C. / Anemia in young patients with ischaemic stroke. In: European Journal of Neurology. 2015 ; Vol. 22, No. 6. pp. 948-953.
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abstract = "Background and purpose: To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non-CeAD-IS patients). Methods: The study sample comprised all patients from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) study without pre-existing disability and with documentation of stroke severity and hemoglobin (Hb) concentration on admission. Anemia was classified as mild (Hb <12 g/dl in women and Hb <13 g/dl in men) or moderate to severe (Hb <10 g/dl in women and Hb <11 g/dl in men). Stroke severity on admission was assessed with the National Institutes of Health Stroke Scale (NIHSS). Outcome after 3 months was assessed with the modified Rankin Scale (mRS-3mo). Unfavorable outcome was defined as mRS-3mo ≥ 3. Results: Amongst 1206 study patients (691 CeAD and 515 non-CeAD), 87 (7.2{\%}) had anemia, which was moderate to severe in 18 (1.5{\%}) patients. Anemia was associated with female sex in both study samples, but no further associations with risk factors or comorbidities were observed. In CeAD patients, anemia was associated with occurrence of stroke (P = 0.042). In both study samples, anemic patients had more severe strokes (CeAD, P = 0.023; non-CeAD, P = 0.005). Functional outcome was not associated with anemia in general, but moderate to severe anemia was significantly associated with unfavorable outcome (P = 0.004). Conclusion: Anemia on admission was associated with stroke in CeAD patients and with more severe strokes in both study samples. Moderate to severe anemia may predict unfavorable outcome.",
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AU - Kellert, L.

AU - Kloss, M.

AU - Pezzini, A.

AU - Metso, T. M.

AU - Metso, A. J.

AU - Debette, S.

AU - Leys, D.

AU - Caso, V.

AU - Thijs, V.

AU - Bersano, A.

AU - Touzé, E.

AU - Tatlisumak, T.

AU - Gensicke, H.

AU - Lyrer, P. A.

AU - Bösel, J.

AU - Engelter, S. T.

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N2 - Background and purpose: To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non-CeAD-IS patients). Methods: The study sample comprised all patients from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) study without pre-existing disability and with documentation of stroke severity and hemoglobin (Hb) concentration on admission. Anemia was classified as mild (Hb <12 g/dl in women and Hb <13 g/dl in men) or moderate to severe (Hb <10 g/dl in women and Hb <11 g/dl in men). Stroke severity on admission was assessed with the National Institutes of Health Stroke Scale (NIHSS). Outcome after 3 months was assessed with the modified Rankin Scale (mRS-3mo). Unfavorable outcome was defined as mRS-3mo ≥ 3. Results: Amongst 1206 study patients (691 CeAD and 515 non-CeAD), 87 (7.2%) had anemia, which was moderate to severe in 18 (1.5%) patients. Anemia was associated with female sex in both study samples, but no further associations with risk factors or comorbidities were observed. In CeAD patients, anemia was associated with occurrence of stroke (P = 0.042). In both study samples, anemic patients had more severe strokes (CeAD, P = 0.023; non-CeAD, P = 0.005). Functional outcome was not associated with anemia in general, but moderate to severe anemia was significantly associated with unfavorable outcome (P = 0.004). Conclusion: Anemia on admission was associated with stroke in CeAD patients and with more severe strokes in both study samples. Moderate to severe anemia may predict unfavorable outcome.

AB - Background and purpose: To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non-CeAD-IS patients). Methods: The study sample comprised all patients from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) study without pre-existing disability and with documentation of stroke severity and hemoglobin (Hb) concentration on admission. Anemia was classified as mild (Hb <12 g/dl in women and Hb <13 g/dl in men) or moderate to severe (Hb <10 g/dl in women and Hb <11 g/dl in men). Stroke severity on admission was assessed with the National Institutes of Health Stroke Scale (NIHSS). Outcome after 3 months was assessed with the modified Rankin Scale (mRS-3mo). Unfavorable outcome was defined as mRS-3mo ≥ 3. Results: Amongst 1206 study patients (691 CeAD and 515 non-CeAD), 87 (7.2%) had anemia, which was moderate to severe in 18 (1.5%) patients. Anemia was associated with female sex in both study samples, but no further associations with risk factors or comorbidities were observed. In CeAD patients, anemia was associated with occurrence of stroke (P = 0.042). In both study samples, anemic patients had more severe strokes (CeAD, P = 0.023; non-CeAD, P = 0.005). Functional outcome was not associated with anemia in general, but moderate to severe anemia was significantly associated with unfavorable outcome (P = 0.004). Conclusion: Anemia on admission was associated with stroke in CeAD patients and with more severe strokes in both study samples. Moderate to severe anemia may predict unfavorable outcome.

KW - Anemia

KW - Cervical artery dissection

KW - Ischaemic stroke

KW - Stroke severity

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