Anemia is associated with depression in older adults: Results from the InCHIANTI study

Graziano Onder, Brenda W J H Penninx, Matteo Cesari, Stefania Bandinelli, Fulvio Lauretani, Benedetta Bartali, Anna Maria Gori, Marco Pahor, Luigi Ferrucci

Research output: Contribution to journalArticle

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Abstract

Background. Depression is a common disorder among older adults, and it has been associated with adverse outcomes, including increased risk of morbidity and mortality as well as incomplete or delayed recovery from illness and disability. The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community. Methods. We used data from the "Invecchiare in Chianti" (Aging in the Chianti area, InCHIANTI) study, a prospective population-based study of older people living in the community. Anemia was defined by the World Health Organization (WHO) criteria: hemoglobin concentration below 12 g/dl in women and below 13 g/dl in men. Depressive symptoms were measured by using the Center for Epidemiological Studies Depression Scale (CES-D). Participants with a CES-D score ≥16 were considered to be depressed. Results. Mean age of the 986 participants was 75 years, and 56% were female; 313 (32%) study participants were depressed. Anemia was recorded in 48 of the 313 (15%) participants with depression and in 53 of the 673 (8%) participants without depression (p <.001). After adjusting for potential confounders, depression was associated with a significant higher risk of anemia (odds ratio = 1.93; 95% confidence interval, 1.19-3.13). The risk of anemia progressively and significantly increased with increasing CES-D score (signifying more severe depression). Compared with nondepressed participants (CES-D score 26), respectively (p for linear trend= .01). Conclusions. Depressive symptoms are associated with anemia in a general population of older persons living in the community.

Original languageEnglish
Pages (from-to)1168-1172
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume60
Issue number9
Publication statusPublished - Sep 2005

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Anemia
Depression
Epidemiologic Studies
Population
Hemoglobins
Odds Ratio
Prospective Studies
Confidence Intervals
Morbidity
Mortality

ASJC Scopus subject areas

  • Ageing

Cite this

Onder, G., Penninx, B. W. J. H., Cesari, M., Bandinelli, S., Lauretani, F., Bartali, B., ... Ferrucci, L. (2005). Anemia is associated with depression in older adults: Results from the InCHIANTI study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 60(9), 1168-1172.

Anemia is associated with depression in older adults : Results from the InCHIANTI study. / Onder, Graziano; Penninx, Brenda W J H; Cesari, Matteo; Bandinelli, Stefania; Lauretani, Fulvio; Bartali, Benedetta; Gori, Anna Maria; Pahor, Marco; Ferrucci, Luigi.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 60, No. 9, 09.2005, p. 1168-1172.

Research output: Contribution to journalArticle

Onder, G, Penninx, BWJH, Cesari, M, Bandinelli, S, Lauretani, F, Bartali, B, Gori, AM, Pahor, M & Ferrucci, L 2005, 'Anemia is associated with depression in older adults: Results from the InCHIANTI study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 60, no. 9, pp. 1168-1172.
Onder, Graziano ; Penninx, Brenda W J H ; Cesari, Matteo ; Bandinelli, Stefania ; Lauretani, Fulvio ; Bartali, Benedetta ; Gori, Anna Maria ; Pahor, Marco ; Ferrucci, Luigi. / Anemia is associated with depression in older adults : Results from the InCHIANTI study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2005 ; Vol. 60, No. 9. pp. 1168-1172.
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T2 - Results from the InCHIANTI study

AU - Onder, Graziano

AU - Penninx, Brenda W J H

AU - Cesari, Matteo

AU - Bandinelli, Stefania

AU - Lauretani, Fulvio

AU - Bartali, Benedetta

AU - Gori, Anna Maria

AU - Pahor, Marco

AU - Ferrucci, Luigi

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N2 - Background. Depression is a common disorder among older adults, and it has been associated with adverse outcomes, including increased risk of morbidity and mortality as well as incomplete or delayed recovery from illness and disability. The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community. Methods. We used data from the "Invecchiare in Chianti" (Aging in the Chianti area, InCHIANTI) study, a prospective population-based study of older people living in the community. Anemia was defined by the World Health Organization (WHO) criteria: hemoglobin concentration below 12 g/dl in women and below 13 g/dl in men. Depressive symptoms were measured by using the Center for Epidemiological Studies Depression Scale (CES-D). Participants with a CES-D score ≥16 were considered to be depressed. Results. Mean age of the 986 participants was 75 years, and 56% were female; 313 (32%) study participants were depressed. Anemia was recorded in 48 of the 313 (15%) participants with depression and in 53 of the 673 (8%) participants without depression (p <.001). After adjusting for potential confounders, depression was associated with a significant higher risk of anemia (odds ratio = 1.93; 95% confidence interval, 1.19-3.13). The risk of anemia progressively and significantly increased with increasing CES-D score (signifying more severe depression). Compared with nondepressed participants (CES-D score 26), respectively (p for linear trend= .01). Conclusions. Depressive symptoms are associated with anemia in a general population of older persons living in the community.

AB - Background. Depression is a common disorder among older adults, and it has been associated with adverse outcomes, including increased risk of morbidity and mortality as well as incomplete or delayed recovery from illness and disability. The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community. Methods. We used data from the "Invecchiare in Chianti" (Aging in the Chianti area, InCHIANTI) study, a prospective population-based study of older people living in the community. Anemia was defined by the World Health Organization (WHO) criteria: hemoglobin concentration below 12 g/dl in women and below 13 g/dl in men. Depressive symptoms were measured by using the Center for Epidemiological Studies Depression Scale (CES-D). Participants with a CES-D score ≥16 were considered to be depressed. Results. Mean age of the 986 participants was 75 years, and 56% were female; 313 (32%) study participants were depressed. Anemia was recorded in 48 of the 313 (15%) participants with depression and in 53 of the 673 (8%) participants without depression (p <.001). After adjusting for potential confounders, depression was associated with a significant higher risk of anemia (odds ratio = 1.93; 95% confidence interval, 1.19-3.13). The risk of anemia progressively and significantly increased with increasing CES-D score (signifying more severe depression). Compared with nondepressed participants (CES-D score 26), respectively (p for linear trend= .01). Conclusions. Depressive symptoms are associated with anemia in a general population of older persons living in the community.

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