Anergy: The CLL cell limbo

Federico Caligaris-Cappio

doi:10.1182/blood-2014-04-565408

Anergy: The CLL cell limbo

Federico Caligaris-Cappio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In this issue of Blood, Duckworth et al find that in chronic lymphocytic leukemia (CLL), malignant cell anergy is associated with failure of inducing PRDM1 (BLIMP1), a critical regulator of differentiation into plasma cells, and that epigenetic modifications account for such failure. These findings link two major problems of CLL cells, the anergic response to B-cell receptor (BCR) stimulation and the incapacity to differentiate.

Original language	English
Pages (from-to)	3214-3215
Number of pages	2
Journal	Blood
Volume	123
Issue number	21
DOIs	https://doi.org/10.1182/blood-2014-04-565408
Publication status	Published - May 22 2014

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

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abstract = "In this issue of Blood, Duckworth et al find that in chronic lymphocytic leukemia (CLL), malignant cell anergy is associated with failure of inducing PRDM1 (BLIMP1), a critical regulator of differentiation into plasma cells, and that epigenetic modifications account for such failure. These findings link two major problems of CLL cells, the anergic response to B-cell receptor (BCR) stimulation and the incapacity to differentiate.",

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