Abstract
In this issue of Blood, Duckworth et al find that in chronic lymphocytic leukemia (CLL), malignant cell anergy is associated with failure of inducing PRDM1 (BLIMP1), a critical regulator of differentiation into plasma cells, and that epigenetic modifications account for such failure. These findings link two major problems of CLL cells, the anergic response to B-cell receptor (BCR) stimulation and the incapacity to differentiate.
Original language | English |
---|---|
Pages (from-to) | 3214-3215 |
Number of pages | 2 |
Journal | Blood |
Volume | 123 |
Issue number | 21 |
DOIs | |
Publication status | Published - May 22 2014 |
ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology