Anergy: The CLL cell limbo

Federico Caligaris-Cappio

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Blood, Duckworth et al find that in chronic lymphocytic leukemia (CLL), malignant cell anergy is associated with failure of inducing PRDM1 (BLIMP1), a critical regulator of differentiation into plasma cells, and that epigenetic modifications account for such failure. These findings link two major problems of CLL cells, the anergic response to B-cell receptor (BCR) stimulation and the incapacity to differentiate.

Original languageEnglish
Pages (from-to)3214-3215
Number of pages2
JournalBlood
Volume123
Issue number21
DOIs
Publication statusPublished - May 22 2014

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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