Anesthesia in laparoscopic cholecystectomy: Evaluation of the use of nitrous oxide

M. Antonini, R. R. D'Errico, G. Della Rocca, P. Oliva, C. Coccia, E. Pastore

Research output: Contribution to journalArticlepeer-review


The aim of our study is to evaluate the clinical effects of N2O during laparoscopic cholecystectomy. Forty consecutive patients were randomly distributed to receive air/O2 or N2O/O2 during artificial ventilation and ondansetron (4 mg i.v.) or placebo after surgery. Our evaluation parameters were as follows: the surgeon's judgement on the extent of bowel distention, the pre- and postoperative abdominal circumference, the total amount of fentanyl administered, the incidence of postoperative nausea and vomiting, the recovery time of bowel functions. There were no statistically significant differences in the observed parameters between the groups. Our data confirm the safety of N2O during laparoscopic cholecystectomy and the absence of major clinical effects.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalActa Anaesthesiologica Italica
Issue number2 SUPPL.
Publication statusPublished - 1994


  • General anaesthesia
  • Laparoscopic cholecystectomy
  • Nitrous oxide

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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