Angina and normal coronary arteries in women: Gynecologic findings

P. M. Sarrel, D. Lindsay, G. M C Rosano, P. A. Poole-Wilson

Research output: Contribution to journalArticlepeer-review


Objectives: Our aim was to evaluate the hypotheses that women with severe angina and normal coronary arteries (syndrome X) have an increased incidence of hysterectomy and show a positive cardiac response to 17β-estradiol replacement therapy. Study design: The gynecologic histories of 30 women with syndrome X were determined. Anginal and 17β-estradiol insufficiency symptoms were recorded daily for 1 month. Subsequently, 20 of the women underwent hyperemic response testing before and after 2 months of estrogen replacement therapy. Hyperemic response results were compared with those of 12 asymptomatic post-menopausal women not receiving estrogen replacement therapy. Symptoms were recorded daily during estrogen replacement therapy. Results: A total of 18 women (60%) underwent hysterectomy. All were experiencing hot flushes. Hyperemic response was diminished in women with syndrome X compared with controls. Hyperemic response increased and anginal symptoms decreased during estrogen replacement therapy. Conclusion: The incidence of hysterectomy was increased and estrogen replacement therapy alleviated cardiac symptoms and enhanced hyperemic response in a group of women with syndrome X.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
Publication statusPublished - 1992


  • angina
  • estrogen
  • hysterectomy
  • syndrome X
  • vasodilatory reserve

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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