Angina-induced protection against myocardial infarction in adult and elderly patients: A loss of preconditioning mechanism in the aging heart?

Pasquale Abete, Nicola Ferrara, Francesco Cacciatore, Alfredo Madrid, Sabatino Bianco, Claudio Calabrese, Claudio Napoli, Paola Scognamiglio, Ornella Bollella, Angelo Cioppa, Giancarlo Longobardi, Franco Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The present study examined whether angina 48 h before myocardial infarction provides protection in adult and elderly patients. Background: The mortality rate for coronary artery disease is greater in elderly than in young patients. In experimental studies, ischemic preconditioning affords an endogenous form of protection against ischemia- reperfusion injury in adult but not in senescent hearts. Angina before myocardial infarction, a clinical equivalent of experimental ischemic preconditioning, has a protective effect in adult patients. It is not known whether angina before myocardial infarction is also protective in aged patients. Methods: We retrospectively verified whether antecedent angina within 48 h of myocardial infarction exerts a beneficial effect on in- hospital outcomes in adult (

Original languageEnglish
Pages (from-to)947-954
Number of pages8
JournalJournal of the American College of Cardiology
Volume30
Issue number4
DOIs
Publication statusPublished - Oct 1997

ASJC Scopus subject areas

  • Nursing(all)

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