Angioarchitectural features of brain arteriovenous malformations associated with seizures: A single Center retrospective series

C. L. Sturiale, L. Rigante, A. Puca, G. Di Lella, A. Albanese, E. Marchese, C. Di Rocco, G. Maira, G. Colicchio

Research output: Contribution to journalArticle

Abstract

Background and purpose: Epileptic seizures account for 24-40% of all clinical onsets in patients with brain arteriovenous malformations (AVMs). Methods: We retrospectively reviewed the angioarchitectural features of AVMs associated with seizures in 168 patients admitted to our Department from 1997 to 2012. Patients were dichotomized according to demographic characteristics, type of treatment, bleeding occurrence, and morphological and topographic features. Clinical status at admission and discharge was also recorded. The association of each one of these variables with seizures occurrence was statistically tested. Continuous variables and outcome were compared with Student's t-test, whereas categorical ones were compared using Fisher's exact test. The independent contribution of some seizures predictors was assessed with a logistic regression model. Associations were considered significant for P4cm (P=0.001) and those fed by dilated arterial feeders (P=0.02) were associated with increased risk of seizures. A higher risk of seizures occurrence was also observed in cortical AVMs compared with deeper ones (75.5% vs. 55.4%; P=0.01), and in AVMs fed by middle and posterior cerebral arteries branches compared with the other vessels (81.6% vs. 45.3%; P4cm also appeared as an independent risk factor of seizures occurrence (OR 2.82; 95% CI, 1.26-6.31; P=0.009) at logistic regression analysis. Conclusions: AVM morphology, especially nidus dimension, appeared to more significantly influence seizures occurrence than their topography.

Original languageEnglish
Pages (from-to)849-855
Number of pages7
JournalEuropean Journal of Neurology
Volume20
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • Angioarchitecture
  • Cerebral AVM
  • Cerebrovascular malformation
  • Epilepsy
  • Nidus
  • Seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Sturiale, C. L., Rigante, L., Puca, A., Di Lella, G., Albanese, A., Marchese, E., Di Rocco, C., Maira, G., & Colicchio, G. (2013). Angioarchitectural features of brain arteriovenous malformations associated with seizures: A single Center retrospective series. European Journal of Neurology, 20(5), 849-855. https://doi.org/10.1111/ene.12085