Angiocentric and intravascular lymphomas

D. Tomasini, E. Berti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Under the generic diagnosis of angiocentric and intravascular lymphomas are included several subtypes of lymphomas histopathologically characterized either by the predominantly endovascular-endoluminal presence of neoplastic lymphocytes of B-T or NK/T cell origin, or by a pathologic process centered around a blood vessels secondarily infiltrated and invaded by the spreading infiltrate. This group of lymphoproliferative disorders is heterogeneous regarding phenotype, but they share common features that are multiorgan involvement, worse prognosis, and, frequently Ebstein-Barr virus (EBV) genomic integration. At onset, some of these rare lymphomas, e.g. intravascular large cell lymphoma or lymphomatoid granulomatosis (Liebow dieases), are misdiagnosed as inflammatory diseases. The actual treatments of these disorders are based upon chemotherapy and/or chemotherapy plus bone marrow transplantation with variable results. Therapeutic approaches for EBV related angiocentric and intravascular lymphomas, similarly to those employed for other viral induced lymphoproliferative disease would comprise the employment of chemotherapy together with drugs able to interfere with viral infection. Such an approach has been used in rare cases of EBV-positive diffuse large B-cell lymphoma of the elderly, a lymphoproliferative disorders which development is linked to immunosuppression due to senescence. The present review will focus on intravascular and angiocentric lymphomas providing histopathologic, immunophenotypical and molecular data useful to overcome to a specific diagnosis and to differentiate them from other lymphoproliferative disorders showing a secondary vascular engulfment and infiltration and some vasculitides showing overlapping histopathologic features.

Original languageEnglish
Pages (from-to)95-113
Number of pages19
JournalGiornale Italiano di Dermatologia e Venereologia
Volume150
Issue number1
Publication statusPublished - Feb 1 2015

Fingerprint

Lymphoma
Lymphoproliferative Disorders
Drug Therapy
Blood Vessels
Lymphomatoid Granulomatosis
Virus Integration
Viruses
Lymphoma, Large B-Cell, Diffuse
Virus Diseases
Pathologic Processes
Vasculitis
Diagnostic Errors
Bone Marrow Transplantation
Natural Killer Cells
Immunosuppression
Lymphocytes
T-Lymphocytes
Phenotype
Therapeutics
Pharmaceutical Preparations

Keywords

  • Diagnosis
  • Lymphoma, large Bcell, diffuse
  • Lymphoma, non-Hodgkin

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Angiocentric and intravascular lymphomas. / Tomasini, D.; Berti, E.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 150, No. 1, 01.02.2015, p. 95-113.

Research output: Contribution to journalArticle

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