Angiogenesis and anti-angiogenesis in hematological malignancies

Domenico Ribatti

Research output: Book/ReportBook

Abstract

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called "vascular niche", indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

Original languageEnglish
PublisherSpringer Netherlands
Number of pages111
ISBN (Print)9789401780353, 940178034X, 9789401780346
DOIs
Publication statusPublished - Oct 1 2014

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Hematologic Neoplasms
Blood Vessels
Stem Cells
Endothelial Cells
Neoplasms
Pericytes
Cytokine Receptors
Myelodysplastic Syndromes
Osteoclasts
Hematopoietic Stem Cells
Osteoblasts
Multiple Myeloma
Mesenchymal Stromal Cells
Mast Cells
Smooth Muscle Myocytes
Lymphoma
Leukemia
Fibroblasts
Bone Marrow
Macrophages

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Angiogenesis and anti-angiogenesis in hematological malignancies. / Ribatti, Domenico.

Springer Netherlands, 2014. 111 p.

Research output: Book/ReportBook

Ribatti, Domenico. / Angiogenesis and anti-angiogenesis in hematological malignancies. Springer Netherlands, 2014. 111 p.
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