Angiogenesis and anti-angiogenesis in hepatocellular carcinoma

Domenico Ribatti, Angelo Vacca, Beatrice Nico, Domenico Sansonno, Franco Dammacco

Research output: Contribution to journalArticlepeer-review


Experimental and clinical data indicate that in human hepatocellular carcinoma (HCC) tumor progression is associated with angiogenesis and that an increase in microvascular density is associated with a poor prognosis. This review summarizes the literature concerning the relationship between angiogenesis and progression in HCC. It is becoming increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed.

Original languageEnglish
Pages (from-to)437-444
Number of pages8
JournalCancer Treatment Reviews
Issue number6
Publication statusPublished - Oct 2006


  • Angiogenesis
  • Anti-angiogenesis
  • Hepatocellular carcinoma
  • Tumor progression

ASJC Scopus subject areas

  • Oncology
  • Urology


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