Angiogenesis and anti-angiogenesis in neuroblastoma

D. Ribatti, A. Vacca, B. Nico, G. De Falco, P. Giuseppe Montaldo, M. Ponzoni

Research output: Contribution to journalArticle

Abstract

Angiogenesis is a biological process by which new capillaries are formed from pre-existing vessels. It occurs in physiological and pathological conditions, such as tumours, where a specific critical turning point is the transition from the avascular to the vascular phase. Tumour angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells that able to stimulate the growth of the host's blood vessels. This review summarises the literature concerning the relationship between angiogenesis and progression in human neuroblastoma, the most common extracranial solid tumour of infancy and childhood. It is becoming increasingly evident that agents which interfere with blood vessel formation also block tumour progression. Accordingly, anti-angiogenic tumour therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block neuroblastoma progression are reviewed.

Original languageEnglish
Pages (from-to)750-757
Number of pages8
JournalEuropean Journal of Cancer
Volume38
Issue number6
DOIs
Publication statusPublished - 2002

Keywords

  • Angiogenesis
  • Angiostatic molecules
  • Retinoic acid
  • Tumour progression

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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