Angiogenesis and antiangiogenic agents in cervical cancer

Federica Tomao, Anselmo Papa, Luigi Rossi, Eleonora Zaccarelli, Davide Caruso, Federica Zoratto, Pierluigi Benedetti Panici, Silverio Tomao

Research output: Contribution to journalArticle

Abstract

Standard treatment of cervical cancer (CC) consists of surgery in the early stages and of chemoradiation in locally advanced disease. Metastatic CC has a poor prognosis and is usually treated with palliative platinum-based chemotherapy. Current chemotherapeutic regimens are associated with significant adverse effects and only limited activity, making identification of active and tolerable novel targeted agents a high priority. Angiogenesis is a complex process that plays a crucial role in the development of many types of cancer. The dominant role of angiogenesis in CC seems to be directly related to human papillomavirus-related inhibition of p53 and stabilization of hypoxia-inducible factor-1α. Both of these mechanisms are able to increase expression of vascular endothelial growth factor (VEGF). Activation of VEGF promotes endothelial cell proliferation and migration, favoring formation of new blood vessels and increasing permeability of existing blood vessels. Since bevacizumab, a recombinant humanized monoclonal antibody binding to all isoforms of VEGF, has been demonstrated to significantly improve survival in gynecologic cancer, some recent clinical research has explored the possibility of using noveltherapies directed toward inhibition of angiogenesis in CC too. Here we review the main results from studies concerning the use of antiangiogenic drugs that are being investigated for the treatment of CC.

Original languageEnglish
Pages (from-to)2237-2248
Number of pages12
JournalOncoTargets and Therapy
Volume7
DOIs
Publication statusPublished - Dec 3 2014

    Fingerprint

Keywords

  • Angiogenesis
  • Bevacizumab
  • Cervical cancer
  • Human papillomavirus
  • Target therapies

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Tomao, F., Papa, A., Rossi, L., Zaccarelli, E., Caruso, D., Zoratto, F., Panici, P. B., & Tomao, S. (2014). Angiogenesis and antiangiogenic agents in cervical cancer. OncoTargets and Therapy, 7, 2237-2248. https://doi.org/10.2147/OTT.S68286