Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas

Domenico Ribatti, Angelo Vacca, Andrea Marzullo, Beatrice Nico, Roberta Ria, Luisa Roncali, Franco Dammacco

Research output: Contribution to journalArticle


Node biopsies of 16 benign lymphadenopathies and 72 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for counts of microvessels, total metachromatic mast cells (MCs) and MCs expressing tryptase, an angiogenesis- inducing molecule. Counts were higher in B-NHLs. When grouped according to the Working Formulation (WF) malignancy grades, they were significantly higher in low-grade B-NHLs vs. lymphadenopathies and intermediate-grade vs. low-grade tumors and there was a further increase in the high-grade tumors. A high correlation was demonstrated in all groups of tissues between microvessel counts and both total metachromatic and tryptase-reactive MCs. These results suggest that angiogenesis in B-NHLs increases with their progression, and that MCs cooperate in its induction via the tryptase contained in their secretory granules.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalInternational Journal of Cancer
Issue number2
Publication statusPublished - Jan 15 2000


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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