Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases

D. Ribatti, N. Finato, E. Crivellato, D. Guidolin, V. Longo, D. Mangieri, B. Nico, A. Vacca, C. A. Beltrami

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: An increasing number of mast cells have been reported in angiogenesis associated with solid and haematopoietic tumours. Data concerning the number of mast cells in neoplastic lymph nodes and their relationship with microvessel density are controversial. The aim was to correlate the extent of angiogenesis with the number of mast cells reactive with tryptase in biopsy specimens of sentinel lymph nodes with and without micrometastases obtained from patients with breast cancer. Methods and results: Specimens from sentinel lymph nodes obtained from 80 patients (40 with and 40 without micrometastases) were investigated immunohistochemically by using anti-CD31 and anti-tryptase antibodies. Angiogenesis, measured as microvessel counts, increased in parallel with the number of tryptase-positive mast cells and their values were significantly higher in lymph nodes with micrometastases compared with those without. Conclusions: Tryptase-positive mast cells may contribute, at least in part, to angiogenesis occurring in sentinel lymph nodes with micrometastases from patients with breast cancer.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalHistopathology
Volume51
Issue number6
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Angiogenesis
  • Breast cancer
  • Mast cell
  • Sentinel lymph node
  • Tryptase

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Fingerprint

Dive into the research topics of 'Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases'. Together they form a unique fingerprint.

Cite this