Angiogenesis and Melanoma

Domenico Ribatti, Tiziana Annese, Vito Longo

Research output: Contribution to journalArticlepeer-review

Abstract

Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host's blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.

Original languageEnglish
Pages (from-to)114-132
Number of pages19
JournalCancers
Volume2
Issue number1
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Angiogenesis
  • Antiangiogenesis
  • Human melanoma
  • Tumor progression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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