Angiogenesis and vasculogenesis in multiple myeloma: Role of inflammatory cells

Angelo Vacca, Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Angiogenesis plays a central role in the progression of both solid and hematologic tumors. We have focused our attention on multiple myeloma (MM) and on bone marrow stromal cells. These, in fact, both support tumor cell survival and participate in angiogenesis by releasing a broad number of angiogenic cytokines. Macrophages and mast cells may participate in this process through other mechanisms, such as vasculogenic mimicry. Lastly, it has been shown that hematopoietic stem and progenitor cells (HSPCs) are involved in vasculogenesis in MM.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Volume183
DOIs
Publication statusPublished - 2011

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Hematopoietic Stem Cells
Multiple Myeloma
Mesenchymal Stromal Cells
Mast Cells
Neoplasms
Cell Survival
Macrophages
Cytokines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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