Angiogenesis at the interface between basic and clinical research

A. Albini, D. Noonan, L. Santi

Research output: Contribution to journalArticlepeer-review

Abstract

The field of antiangiogenesis has shown a remarkably rapid evolution from discovery at the bench to translation into the clinic. Currently a wide variety of compounds are in clinical trial as inhibitors of angiogenesis, and new compounds are being frequently added. The target cell of most angiogenesis inhibitors is the endothelial cell, with inhibitors that selectively affect a number of endothelial cell functions acquired during angiogenesis, including activation, proliferation, migration, invasion and survival. The endothelial cell may also be targeted by chemotherapeutic agents currently in use. The high doses and intermittent treatment schedules used to fight resistant tumor cells may be altered towards lower doses and chronic administration to obtain selective inhibition of angiogenic factor-stimulated endothelial cells as adjuvant therapy. Finally, gene therapy is a promising route for the delivery of novel protein inhibitors of angiogenesis, and is actively being investigated.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalInternational Journal of Biological Markers
Volume14
Issue number4
Publication statusPublished - 1999

Keywords

  • Angiogenesis
  • Chemotherapy
  • Gene therapy
  • Inhibitors

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

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