Angiogenesis: Basic and clinical aspects

Domenico Ribatti, Angelo Vacca, Beatrice Nico, Marco Presta, Luisa Roncali

Research output: Contribution to journalArticlepeer-review


The cardiovascular system is the first functional organ system to develop in the vertebrate em-bryo. A widely accepted view is that blood vessels arise through two mechanisms during develop-ment, vasculogenesis and angiogenesis. New vessels in the adult arise mainly through angiogenesis, although vasculogenesis also may occur. The existence of a postnatal vasculogenesis is also sup-ported by the evidence that both endothelial cells and endothelial precursor cells co-exist in the cir-culation. Angiogenesis is a biological process by which new capillaries are formed and it occurs in many physiological and pathological conditions. It is controlled by the net balance between molecules that have positive and negative regulatory activity and this concept had led to the notion of the "ang-iogenic switch", depending on an increased production of one or more of the positive regulators of angiogenesis. Considerable benefit can be derived in the clinical setting from manipulating angiogenesis, ei-ther positively or negatively. There is a variety of important clinical situations in which it would be desiderable to promote angiogenic processes, such as situations in which it would be desiderable to promote angiogenic processes, such as for the induction of collateral vascularization in an ischemic heart or limb. Conversely, there are pathologic conditions in which preventing angiogenic processes could be useful in the treatment of a growing tumor or a chronic inflammatory process.

Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalItalian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
Issue number1
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Anatomy
  • Embryology
  • Medicine(all)


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