Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 correlate with progression in human neuroblastoma

D. Ribatti, G. Surico, A. Vacca, F. De Leonardis, G. Lastilla, P. G. Montaldo, N. Rigillo, M. Ponzoni

Research output: Contribution to journalArticle

Abstract

In human tumors changes in angiogenesis and expression of extracellular matrix-degrading enzymes occur simultaneously during invasion and metastasis. Tissues from 20 biopsies of human neuroblastoma (NB) were investigated immunohistochemically by using an antibody against factor VIII to determine their microvessel number, and by in situ hybridisation to determine the expression of mRNA of the matrix metalloproteinase-2 (MMP-2) and MMP-9. The extent of angiogenesis and the expression of the MMP-2 and MMP-9 mRNA were upregulated in advancing stages. These in situ data suggest that angiogenesis and degradation of extracellular matrix occur simultaneously with NB tumor progression.

Original languageEnglish
Pages (from-to)1161-1168
Number of pages8
JournalLife Sciences
Volume68
Issue number10
DOIs
Publication statusPublished - Jan 26 2001

Keywords

  • Angiogenesis
  • Matrix metalloproteinases
  • Neuroblastoma

ASJC Scopus subject areas

  • Pharmacology

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