Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas

A. Vacca, D. Ribatti, L. Ruco, F. Giacchetta, B. Nico, F. Quondamatteo, R. Ria, M. Iurlaro, F. Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.

Original languageEnglish
Pages (from-to)965-970
Number of pages6
JournalBritish Journal of Cancer
Volume79
Issue number5-6
DOIs
Publication statusPublished - 1999

Keywords

  • Angiogenesis
  • Macrophage
  • Non-Hodgkin's lymphoma
  • Tumour progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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