Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas

A. Vacca, D. Ribatti, L. Ruco, F. Giacchetta, B. Nico, F. Quondamatteo, R. Ria, M. Iurlaro, F. Dammacco

Research output: Contribution to journalArticle

Abstract

Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.

Original languageEnglish
Pages (from-to)965-970
Number of pages6
JournalBritish Journal of Cancer
Volume79
Issue number5-6
DOIs
Publication statusPublished - 1999

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B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Macrophages
Microvessels
Immunohistochemistry
Neoplasms
Angiogenesis Inducing Agents
Electron Microscopy
Biopsy

Keywords

  • Angiogenesis
  • Macrophage
  • Non-Hodgkin's lymphoma
  • Tumour progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas. / Vacca, A.; Ribatti, D.; Ruco, L.; Giacchetta, F.; Nico, B.; Quondamatteo, F.; Ria, R.; Iurlaro, M.; Dammacco, F.

In: British Journal of Cancer, Vol. 79, No. 5-6, 1999, p. 965-970.

Research output: Contribution to journalArticle

Vacca, A, Ribatti, D, Ruco, L, Giacchetta, F, Nico, B, Quondamatteo, F, Ria, R, Iurlaro, M & Dammacco, F 1999, 'Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas', British Journal of Cancer, vol. 79, no. 5-6, pp. 965-970. https://doi.org/10.1038/sj.bjc.6690154
Vacca, A. ; Ribatti, D. ; Ruco, L. ; Giacchetta, F. ; Nico, B. ; Quondamatteo, F. ; Ria, R. ; Iurlaro, M. ; Dammacco, F. / Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas. In: British Journal of Cancer. 1999 ; Vol. 79, No. 5-6. pp. 965-970.
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AU - Vacca, A.

AU - Ribatti, D.

AU - Ruco, L.

AU - Giacchetta, F.

AU - Nico, B.

AU - Quondamatteo, F.

AU - Ria, R.

AU - Iurlaro, M.

AU - Dammacco, F.

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AB - Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.

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