TY - JOUR
T1 - Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
AU - Vacca, A.
AU - Ribatti, D.
AU - Ruco, L.
AU - Giacchetta, F.
AU - Nico, B.
AU - Quondamatteo, F.
AU - Ria, R.
AU - Iurlaro, M.
AU - Dammacco, F.
PY - 1999
Y1 - 1999
N2 - Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.
AB - Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.
KW - Angiogenesis
KW - Macrophage
KW - Non-Hodgkin's lymphoma
KW - Tumour progression
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U2 - 10.1038/sj.bjc.6690154
DO - 10.1038/sj.bjc.6690154
M3 - Article
C2 - 10070898
AN - SCOPUS:0033002831
VL - 79
SP - 965
EP - 970
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 5-6
ER -