L'angiogenesi nel carcinoma della mammella

Translated title of the contribution: Angiogenesis in breast cancer

Laura Medri, Oriana Nanni, Annalisa Volpi, Emanuela Scarpi, Alessandra Dubini, Angela Riccobon, Manuela Balzi, Simonetta Bianchi, Dino Amadori, Ariele Saragoni

Research output: Contribution to journalArticlepeer-review


Angiogenesis, the development of new blood vessels, is essential for tumour growth, and metastatic spread. Microvessel density (MVD) of breast cancer is widely regarded as a prognostic factor, but the results from other studies have produced conflicting results. The present study was performed in order to define the prognostic value of MVD on a series of 378 node-negative breast cancer patients. Microvessels were stained using Factor-VIII antibody. MVD was determined independently by 2 observers according to Weidner's method. In parallel, cell proliferation, oestrogen and progesterone receptors were evaluated. Tumour MVD varied greatly from tumour to tumour (2 to 232 MV/mm2) and was unrelated to patient age and menopausal status, or to tumour size, histology and receptor status. A significant (p = 0.004) but inverse correlation (rs = -0.188) was observed with cell proliferation. Univariate analysis, using 40 MV/mm2 as cut-off, showed an inverse relation with 5-year relapse-free survival rate (82% vs 71%, p = 0.018). This finding was limited to very small, slowly proliferating and ER-negative tumours. Multivariate analysis identified tumour size and TLI, as independent prognostic factors. Therefore, on the basis of our results, angiogenesis does not seem to have an independent prognostic value.

Translated title of the contributionAngiogenesis in breast cancer
Original languageItalian
Pages (from-to)185-189
Number of pages5
JournalEuropean Journal of Oncology
Issue number3
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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