TY - JOUR
T1 - L'angiogenesi nel carcinoma della mammella
AU - Medri, Laura
AU - Nanni, Oriana
AU - Volpi, Annalisa
AU - Scarpi, Emanuela
AU - Dubini, Alessandra
AU - Riccobon, Angela
AU - Balzi, Manuela
AU - Bianchi, Simonetta
AU - Amadori, Dino
AU - Saragoni, Ariele
PY - 2002/9
Y1 - 2002/9
N2 - Angiogenesis, the development of new blood vessels, is essential for tumour growth, and metastatic spread. Microvessel density (MVD) of breast cancer is widely regarded as a prognostic factor, but the results from other studies have produced conflicting results. The present study was performed in order to define the prognostic value of MVD on a series of 378 node-negative breast cancer patients. Microvessels were stained using Factor-VIII antibody. MVD was determined independently by 2 observers according to Weidner's method. In parallel, cell proliferation, oestrogen and progesterone receptors were evaluated. Tumour MVD varied greatly from tumour to tumour (2 to 232 MV/mm2) and was unrelated to patient age and menopausal status, or to tumour size, histology and receptor status. A significant (p = 0.004) but inverse correlation (rs = -0.188) was observed with cell proliferation. Univariate analysis, using 40 MV/mm2 as cut-off, showed an inverse relation with 5-year relapse-free survival rate (82% vs 71%, p = 0.018). This finding was limited to very small, slowly proliferating and ER-negative tumours. Multivariate analysis identified tumour size and TLI, as independent prognostic factors. Therefore, on the basis of our results, angiogenesis does not seem to have an independent prognostic value.
AB - Angiogenesis, the development of new blood vessels, is essential for tumour growth, and metastatic spread. Microvessel density (MVD) of breast cancer is widely regarded as a prognostic factor, but the results from other studies have produced conflicting results. The present study was performed in order to define the prognostic value of MVD on a series of 378 node-negative breast cancer patients. Microvessels were stained using Factor-VIII antibody. MVD was determined independently by 2 observers according to Weidner's method. In parallel, cell proliferation, oestrogen and progesterone receptors were evaluated. Tumour MVD varied greatly from tumour to tumour (2 to 232 MV/mm2) and was unrelated to patient age and menopausal status, or to tumour size, histology and receptor status. A significant (p = 0.004) but inverse correlation (rs = -0.188) was observed with cell proliferation. Univariate analysis, using 40 MV/mm2 as cut-off, showed an inverse relation with 5-year relapse-free survival rate (82% vs 71%, p = 0.018). This finding was limited to very small, slowly proliferating and ER-negative tumours. Multivariate analysis identified tumour size and TLI, as independent prognostic factors. Therefore, on the basis of our results, angiogenesis does not seem to have an independent prognostic value.
KW - Angiogenesis
KW - Breast cancer
KW - Microvessel density
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M3 - Articolo
AN - SCOPUS:0036760629
VL - 7
SP - 185
EP - 189
JO - European Journal of Oncology
JF - European Journal of Oncology
SN - 1128-6598
IS - 3
ER -