Angiogenesis in pancreatic ductal adenocarcinoma

A controversial issue

Vito Longo, Oronzo Brunetti, Antonio Gnoni, Stefano Cascinu, Giampietro Gasparini, Vito Lorusso, Domenico Ribatti, Nicola Silvestris

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early loco-regional spread and distant metastases at diagnosis, leading to dismal prognosis with a 5-year overall survival rate moderately over than 5%. This malignancy is largely resistant to chemotherapy and radiation, but the reasons of the refractoriness to the therapies is still unknown. Evidence is accumulating to indicate that the PDAC microenvironment and vascularity strongly contribute to the clinical features of this disease. In particular, PDAC is characterized by excessive dense extracellular matrix deposition associated to vasculature collapse and hypoxia with low drug delivery, explaining at least partly the low efficacy of antiangiogenic drugs in this cancer. Strategies aimed to modulate tumor stroma favoring vasculature perfusion and chemotherapeutics delivery are under investigation.

Original languageEnglish
Pages (from-to)58649-58658
Number of pages10
JournalOncotarget
Volume7
Issue number36
DOIs
Publication statusPublished - 2016

Fingerprint

Adenocarcinoma
Neoplasms
Pharmaceutical Preparations
Extracellular Matrix
Perfusion
Radiation
Neoplasm Metastasis
Drug Therapy
Therapeutics
Hypoxia

Keywords

  • Angiogenesis
  • Desmoplastic reaction
  • Hypoxia
  • Pancreatic ductal adenocarcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

Angiogenesis in pancreatic ductal adenocarcinoma : A controversial issue. / Longo, Vito; Brunetti, Oronzo; Gnoni, Antonio; Cascinu, Stefano; Gasparini, Giampietro; Lorusso, Vito; Ribatti, Domenico; Silvestris, Nicola.

In: Oncotarget, Vol. 7, No. 36, 2016, p. 58649-58658.

Research output: Contribution to journalReview article

Longo, V, Brunetti, O, Gnoni, A, Cascinu, S, Gasparini, G, Lorusso, V, Ribatti, D & Silvestris, N 2016, 'Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue', Oncotarget, vol. 7, no. 36, pp. 58649-58658. https://doi.org/10.18632/oncotarget.10765
Longo, Vito ; Brunetti, Oronzo ; Gnoni, Antonio ; Cascinu, Stefano ; Gasparini, Giampietro ; Lorusso, Vito ; Ribatti, Domenico ; Silvestris, Nicola. / Angiogenesis in pancreatic ductal adenocarcinoma : A controversial issue. In: Oncotarget. 2016 ; Vol. 7, No. 36. pp. 58649-58658.
@article{1b789d97881c48a78e68fe3403c10729,
title = "Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early loco-regional spread and distant metastases at diagnosis, leading to dismal prognosis with a 5-year overall survival rate moderately over than 5{\%}. This malignancy is largely resistant to chemotherapy and radiation, but the reasons of the refractoriness to the therapies is still unknown. Evidence is accumulating to indicate that the PDAC microenvironment and vascularity strongly contribute to the clinical features of this disease. In particular, PDAC is characterized by excessive dense extracellular matrix deposition associated to vasculature collapse and hypoxia with low drug delivery, explaining at least partly the low efficacy of antiangiogenic drugs in this cancer. Strategies aimed to modulate tumor stroma favoring vasculature perfusion and chemotherapeutics delivery are under investigation.",
keywords = "Angiogenesis, Desmoplastic reaction, Hypoxia, Pancreatic ductal adenocarcinoma",
author = "Vito Longo and Oronzo Brunetti and Antonio Gnoni and Stefano Cascinu and Giampietro Gasparini and Vito Lorusso and Domenico Ribatti and Nicola Silvestris",
year = "2016",
doi = "10.18632/oncotarget.10765",
language = "English",
volume = "7",
pages = "58649--58658",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "36",

}

TY - JOUR

T1 - Angiogenesis in pancreatic ductal adenocarcinoma

T2 - A controversial issue

AU - Longo, Vito

AU - Brunetti, Oronzo

AU - Gnoni, Antonio

AU - Cascinu, Stefano

AU - Gasparini, Giampietro

AU - Lorusso, Vito

AU - Ribatti, Domenico

AU - Silvestris, Nicola

PY - 2016

Y1 - 2016

N2 - Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early loco-regional spread and distant metastases at diagnosis, leading to dismal prognosis with a 5-year overall survival rate moderately over than 5%. This malignancy is largely resistant to chemotherapy and radiation, but the reasons of the refractoriness to the therapies is still unknown. Evidence is accumulating to indicate that the PDAC microenvironment and vascularity strongly contribute to the clinical features of this disease. In particular, PDAC is characterized by excessive dense extracellular matrix deposition associated to vasculature collapse and hypoxia with low drug delivery, explaining at least partly the low efficacy of antiangiogenic drugs in this cancer. Strategies aimed to modulate tumor stroma favoring vasculature perfusion and chemotherapeutics delivery are under investigation.

AB - Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early loco-regional spread and distant metastases at diagnosis, leading to dismal prognosis with a 5-year overall survival rate moderately over than 5%. This malignancy is largely resistant to chemotherapy and radiation, but the reasons of the refractoriness to the therapies is still unknown. Evidence is accumulating to indicate that the PDAC microenvironment and vascularity strongly contribute to the clinical features of this disease. In particular, PDAC is characterized by excessive dense extracellular matrix deposition associated to vasculature collapse and hypoxia with low drug delivery, explaining at least partly the low efficacy of antiangiogenic drugs in this cancer. Strategies aimed to modulate tumor stroma favoring vasculature perfusion and chemotherapeutics delivery are under investigation.

KW - Angiogenesis

KW - Desmoplastic reaction

KW - Hypoxia

KW - Pancreatic ductal adenocarcinoma

UR - http://www.scopus.com/inward/record.url?scp=84988432078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988432078&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.10765

DO - 10.18632/oncotarget.10765

M3 - Review article

VL - 7

SP - 58649

EP - 58658

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 36

ER -