Angiogenesis in rheumatoid arthritis

N. Maruotti, F. P. Cantatore, E. Crivellato, A. Vacca, Domenico Ribatti

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

There is much evidence that rheumatoid arthritis is closely linked to angiogenesis. Important angiogenic mediators have been demonstrated in synovium and tenosynovium of rheumatoid joints. VEGF (Vascular Endothelial Growth Factor), expressed in response to soluble mediators such as cytokines and growth factors and its receptors are the best characterized system in the angiogenesis regulation of rheumatoid joints. Moreover, other angiogenic mediators such as platelet-derived growth factor (PDGF), fibroblast growth factor-2 (FGF-2), epidermal growth factor (EGF), insulin-like growth factor (IGF), hepatocyte growth factor (HGF), transforming growth factor beta (TGF-β), tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), IL-6, IL-8, IL-13, IL-15, IL-18, angiogenin, platelet activating factor (PAF), angiopoietin, soluble adhesion molecules, endothelial mediator (endoglin) play an important role in angiogenesis in rheumatoid arthritis. On the other hand, endostatin, thrombospondin-1 and -2 are angiogenic inhibitors in rheumatoid arthritis. The persistence of inflammation in rheumatoid joints is a consequence of an imbalance between these inducers and inhibitors of angiogenesis.

Original languageEnglish
Pages (from-to)557-566
Number of pages10
JournalHistology and Histopathology
Volume21
Issue number4-6
Publication statusPublished - Apr 2006

Fingerprint

Rheumatoid Arthritis
Angiogenesis Inhibitors
Joints
Angiopoietins
Endostatins
Thrombospondin 1
Interleukin-15
Interleukin-18
Hepatocyte Growth Factor
Interleukin-13
Growth Factor Receptors
Synovial Membrane
Angiogenesis Inducing Agents
Platelet Activating Factor
Platelet-Derived Growth Factor
Somatomedins
Fibroblast Growth Factor 2
Interleukin-8
Interleukin-1
Epidermal Growth Factor

Keywords

  • Angiogenesis
  • Anti-angiogenesis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Maruotti, N., Cantatore, F. P., Crivellato, E., Vacca, A., & Ribatti, D. (2006). Angiogenesis in rheumatoid arthritis. Histology and Histopathology, 21(4-6), 557-566.

Angiogenesis in rheumatoid arthritis. / Maruotti, N.; Cantatore, F. P.; Crivellato, E.; Vacca, A.; Ribatti, Domenico.

In: Histology and Histopathology, Vol. 21, No. 4-6, 04.2006, p. 557-566.

Research output: Contribution to journalArticle

Maruotti, N, Cantatore, FP, Crivellato, E, Vacca, A & Ribatti, D 2006, 'Angiogenesis in rheumatoid arthritis', Histology and Histopathology, vol. 21, no. 4-6, pp. 557-566.
Maruotti N, Cantatore FP, Crivellato E, Vacca A, Ribatti D. Angiogenesis in rheumatoid arthritis. Histology and Histopathology. 2006 Apr;21(4-6):557-566.
Maruotti, N. ; Cantatore, F. P. ; Crivellato, E. ; Vacca, A. ; Ribatti, Domenico. / Angiogenesis in rheumatoid arthritis. In: Histology and Histopathology. 2006 ; Vol. 21, No. 4-6. pp. 557-566.
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