Abstract
Vasculitides, including Wegener's granulomatosis, Takayasu's arteritis, giant cell arteritis, Kawasaki disease, Behçet disease, thromboangiitis obliterans and erythema elevatum diutinum, are inflammatory diseases of blood vessel wall characterized by myointimal proliferation, fibrosis and thrombus formation leading to stenosis or occlusion of the vascular lumen, and finally to tissue ischemia. In these diseases the hypoxic environment subsequent to stenosis or occlusion of the vascular lumen is a potent signal for the generation of new blood vessels. Angiogenesis may be a compensatory response to ischemia and to the increased metabolic activity and may be also a further inflammatory stimulus because endothelial cells of newly-formed vessels express adhesion molecules and produce colony-stimulating factors and chemokines for leukocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 476-483 |
| Number of pages | 8 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 26 |
| Issue number | 3 |
| Publication status | Published - May 2008 |
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Keywords
- Angiogenesis
- Inflammation
- Vasculitides
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Angiogenesis in vasculitides. / Maruotti, Nicola; Cantatore, Francesco P.; Nico, Beatrice; Vacca, Angelo; Ribatti, Domenico.
In: Clinical and Experimental Rheumatology, Vol. 26, No. 3, 05.2008, p. 476-483.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiogenesis in vasculitides
AU - Maruotti, Nicola
AU - Cantatore, Francesco P.
AU - Nico, Beatrice
AU - Vacca, Angelo
AU - Ribatti, Domenico
PY - 2008/5
Y1 - 2008/5
N2 - Vasculitides, including Wegener's granulomatosis, Takayasu's arteritis, giant cell arteritis, Kawasaki disease, Behçet disease, thromboangiitis obliterans and erythema elevatum diutinum, are inflammatory diseases of blood vessel wall characterized by myointimal proliferation, fibrosis and thrombus formation leading to stenosis or occlusion of the vascular lumen, and finally to tissue ischemia. In these diseases the hypoxic environment subsequent to stenosis or occlusion of the vascular lumen is a potent signal for the generation of new blood vessels. Angiogenesis may be a compensatory response to ischemia and to the increased metabolic activity and may be also a further inflammatory stimulus because endothelial cells of newly-formed vessels express adhesion molecules and produce colony-stimulating factors and chemokines for leukocytes.
AB - Vasculitides, including Wegener's granulomatosis, Takayasu's arteritis, giant cell arteritis, Kawasaki disease, Behçet disease, thromboangiitis obliterans and erythema elevatum diutinum, are inflammatory diseases of blood vessel wall characterized by myointimal proliferation, fibrosis and thrombus formation leading to stenosis or occlusion of the vascular lumen, and finally to tissue ischemia. In these diseases the hypoxic environment subsequent to stenosis or occlusion of the vascular lumen is a potent signal for the generation of new blood vessels. Angiogenesis may be a compensatory response to ischemia and to the increased metabolic activity and may be also a further inflammatory stimulus because endothelial cells of newly-formed vessels express adhesion molecules and produce colony-stimulating factors and chemokines for leukocytes.
KW - Angiogenesis
KW - Inflammation
KW - Vasculitides
UR - http://www.scopus.com/inward/record.url?scp=48949117166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48949117166&partnerID=8YFLogxK
M3 - Article
C2 - 18578974
AN - SCOPUS:48949117166
VL - 26
SP - 476
EP - 483
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 3
ER -