Angiogenesis induced by B-cell non-Hodgkin's lymphomas. Lack of correlation with tumor malignancy and immunologic phenotype

D. Ribatti, A. Vacca, M. Bertossi, G. De Benedictis, L. Roncali, F. Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

Correlations of malignancy grade, immunologic phenotype and angigenic capacity were studied in B-cell non-Hodgkin's lymphomas grafted onto chorioallantoic membranes of chicken embryos. The angiogenic response elicited by the tumors was significantly greater than the response to normal lymph nodes, but it did not correlate with either the malignancy grade or the immunologic phenotype of the tumors. The elevated angiogenic capacity of neoplastic tissues is confirmed. The results also suggest that the extensive vasoproliferative response required by a rapidly growing tumor is not only controlled by the neoplastic cell population but, probably, by the host-response as well.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalAnticancer Research
Volume10
Issue number2 A
Publication statusPublished - 1990

Keywords

  • chorioallantoic membrane
  • host mononuclear cells
  • lymphoma
  • tumor angiogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Angiogenesis induced by B-cell non-Hodgkin's lymphomas. Lack of correlation with tumor malignancy and immunologic phenotype'. Together they form a unique fingerprint.

Cite this