Abstract
Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.
| Original language | English |
|---|---|
| Pages (from-to) | 695-698 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 120 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 2003 |
Keywords
- Angiogenesis
- Hairy cell leukaemia
- NOD/SCID mice
ASJC Scopus subject areas
- Hematology
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Cite this
Pruneri, G., Bertolini, F., Baldini, L., Valentini, S., Goldaniga, M., Soligo, D., Carboni, N., Viale, G., & Lambertenghi-Deliliers, G. (2003). Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12. British Journal of Haematology, 120(4), 695-698. https://doi.org/10.1046/j.1365-2141.2003.04133.x