Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12

Giancarlo Pruneri, Francesco Bertolini, Luca Baldini, Stefano Valentini, Maria Goldaniga, Davide Soligo, Nadia Carboni, Giuseppe Viale, Giorgio Lambertenghi-Deliliers

Research output: Contribution to journalArticle

Abstract

Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number4
DOIs
Publication statusPublished - Feb 2003

Keywords

  • Angiogenesis
  • Hairy cell leukaemia
  • NOD/SCID mice

ASJC Scopus subject areas

  • Hematology

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