Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12

Giancarlo Pruneri; Francesco Bertolini; Luca Baldini; Stefano Valentini; Maria Goldaniga; Davide Soligo; Nadia Carboni; Giuseppe Viale; Giorgio Lambertenghi-Deliliers

doi:10.1046/j.1365-2141.2003.04133.x

Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12

Giancarlo Pruneri, Francesco Bertolini, Luca Baldini, Stefano Valentini, Maria Goldaniga, Davide Soligo, Nadia Carboni, Giuseppe Viale, Giorgio Lambertenghi-Deliliers

Research output: Contribution to journal › Article › peer-review

Abstract

Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.

Original language	English
Pages (from-to)	695-698
Number of pages	4
Journal	British Journal of Haematology
Volume	120
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2003.04133.x
Publication status	Published - Feb 2003

Keywords

Angiogenesis
Hairy cell leukaemia
NOD/SCID mice

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2003.04133.x

Cite this

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title = "Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12",

abstract = "Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.",

keywords = "Angiogenesis, Hairy cell leukaemia, NOD/SCID mice",

author = "Giancarlo Pruneri and Francesco Bertolini and Luca Baldini and Stefano Valentini and Maria Goldaniga and Davide Soligo and Nadia Carboni and Giuseppe Viale and Giorgio Lambertenghi-Deliliers",

year = "2003",

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doi = "10.1046/j.1365-2141.2003.04133.x",

language = "English",

volume = "120",

pages = "695--698",

journal = "British Journal of Haematology",

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T1 - Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12

AU - Pruneri, Giancarlo

AU - Bertolini, Francesco

AU - Baldini, Luca

AU - Valentini, Stefano

AU - Goldaniga, Maria

AU - Soligo, Davide

AU - Carboni, Nadia

AU - Viale, Giuseppe

AU - Lambertenghi-Deliliers, Giorgio

PY - 2003/2

Y1 - 2003/2

N2 - Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.

AB - Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.

KW - Angiogenesis

KW - Hairy cell leukaemia

KW - NOD/SCID mice

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JO - British Journal of Haematology

JF - British Journal of Haematology

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ER -

Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12

Abstract

Keywords

ASJC Scopus subject areas

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