TY - JOUR
T1 - Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12
AU - Pruneri, Giancarlo
AU - Bertolini, Francesco
AU - Baldini, Luca
AU - Valentini, Stefano
AU - Goldaniga, Maria
AU - Soligo, Davide
AU - Carboni, Nadia
AU - Viale, Giuseppe
AU - Lambertenghi-Deliliers, Giorgio
PY - 2003/2
Y1 - 2003/2
N2 - Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.
AB - Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetice/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-α, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.
KW - Angiogenesis
KW - Hairy cell leukaemia
KW - NOD/SCID mice
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U2 - 10.1046/j.1365-2141.2003.04133.x
DO - 10.1046/j.1365-2141.2003.04133.x
M3 - Article
C2 - 12588359
AN - SCOPUS:0344407508
VL - 120
SP - 695
EP - 698
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 4
ER -