Angiogenesis: Prognostic significance in laryngeal cancer

Fabio Beatrice, Raffaella Cammarota, Carlo Giordano, Simona Corrado, Riccardo Ragona, Alberto Sartoris, Federico Bussolino, Guido Valente

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the role of angiogenesis in the progression of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival with microvessel count (MC) in the hot spot areas of 97 randomly selected caucasian males with LSCC followed for 60 to 90 months after surgery with or without radiotherapy. The results obtained indicate that: a) MC higher than 130 microvessels/mm2 is a cut-off value that distinguished patients who relapsed during the follow up period; b) multivariated analysis indicates that MC (p <0.00001) is an independent predictor of disease free-survival; c) multivariated analysis selectively done on cases with relapse dimonstrates that MC correlates with the presence of metastasis (or/and M) with local relapse (T). We suggest that MC is useful in the assesment of prognosis in LSCC and probably will permit selection of patients that could benefit from anti-angiogenic therapy associated with chemotherapy and/or radiotherapy.

Original languageEnglish
Pages (from-to)4737-4740
Number of pages4
JournalAnticancer Research
Volume18
Issue number6 B
Publication statusPublished - 1998

Keywords

  • Angiogenesis
  • Immunohistochemistry
  • Laryngeal neoplasms
  • Tumor prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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