Abstract
The aim of this study was to evaluate the role of angiogenesis in the progression of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival with microvessel count (MC) in the hot spot areas of 97 randomly selected caucasian males with LSCC followed for 60 to 90 months after surgery with or without radiotherapy. The results obtained indicate that: a) MC higher than 130 microvessels/mm2 is a cut-off value that distinguished patients who relapsed during the follow up period; b) multivariated analysis indicates that MC (p <0.00001) is an independent predictor of disease free-survival; c) multivariated analysis selectively done on cases with relapse dimonstrates that MC correlates with the presence of metastasis (or/and M) with local relapse (T). We suggest that MC is useful in the assesment of prognosis in LSCC and probably will permit selection of patients that could benefit from anti-angiogenic therapy associated with chemotherapy and/or radiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 4737-4740 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 18 |
| Issue number | 6 B |
| Publication status | Published - 1998 |
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Keywords
- Angiogenesis
- Immunohistochemistry
- Laryngeal neoplasms
- Tumor prognosis
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Angiogenesis : Prognostic significance in laryngeal cancer. / Beatrice, Fabio; Cammarota, Raffaella; Giordano, Carlo; Corrado, Simona; Ragona, Riccardo; Sartoris, Alberto; Bussolino, Federico; Valente, Guido.
In: Anticancer Research, Vol. 18, No. 6 B, 1998, p. 4737-4740.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiogenesis
T2 - Prognostic significance in laryngeal cancer
AU - Beatrice, Fabio
AU - Cammarota, Raffaella
AU - Giordano, Carlo
AU - Corrado, Simona
AU - Ragona, Riccardo
AU - Sartoris, Alberto
AU - Bussolino, Federico
AU - Valente, Guido
PY - 1998
Y1 - 1998
N2 - The aim of this study was to evaluate the role of angiogenesis in the progression of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival with microvessel count (MC) in the hot spot areas of 97 randomly selected caucasian males with LSCC followed for 60 to 90 months after surgery with or without radiotherapy. The results obtained indicate that: a) MC higher than 130 microvessels/mm2 is a cut-off value that distinguished patients who relapsed during the follow up period; b) multivariated analysis indicates that MC (p <0.00001) is an independent predictor of disease free-survival; c) multivariated analysis selectively done on cases with relapse dimonstrates that MC correlates with the presence of metastasis (or/and M) with local relapse (T). We suggest that MC is useful in the assesment of prognosis in LSCC and probably will permit selection of patients that could benefit from anti-angiogenic therapy associated with chemotherapy and/or radiotherapy.
AB - The aim of this study was to evaluate the role of angiogenesis in the progression of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival with microvessel count (MC) in the hot spot areas of 97 randomly selected caucasian males with LSCC followed for 60 to 90 months after surgery with or without radiotherapy. The results obtained indicate that: a) MC higher than 130 microvessels/mm2 is a cut-off value that distinguished patients who relapsed during the follow up period; b) multivariated analysis indicates that MC (p <0.00001) is an independent predictor of disease free-survival; c) multivariated analysis selectively done on cases with relapse dimonstrates that MC correlates with the presence of metastasis (or/and M) with local relapse (T). We suggest that MC is useful in the assesment of prognosis in LSCC and probably will permit selection of patients that could benefit from anti-angiogenic therapy associated with chemotherapy and/or radiotherapy.
KW - Angiogenesis
KW - Immunohistochemistry
KW - Laryngeal neoplasms
KW - Tumor prognosis
UR - http://www.scopus.com/inward/record.url?scp=0032420868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032420868&partnerID=8YFLogxK
M3 - Article
C2 - 9891550
AN - SCOPUS:0032420868
VL - 18
SP - 4737
EP - 4740
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6 B
ER -