Abstract
Erythropoietin (Epo) is a low-molecular weight glycoprotein hormone stimulator of erythropoiesis synthesized in the fetal liver and in the adult kidney. Moreover, Epo is a pleiotropic cytokine that exerts diverse biological effects in non-hematopoietic tissues, and angiogenesis is indicated as one of its extra-hematopoietic functions. The involvement of Epo in angiogenesis may be considered as subset of its role in improving overall tissue oxygenation and of its anti-apoptotic role. In this context, Epo may be considered as an endogenous stimulator of vessel growth during tumor progression, and inhibition of Epo signaling might be suggested as a new antiangiogenic therapeutic approach. It is conceivable suppose that the effect of Epo is multifactorial, depending on the type of tumor and level of functionality of Epo receptor expression in tumor cells, as well as on other variables, such as hypoxic stress and degree of anemia.
| Original language | English |
|---|---|
| Pages (from-to) | 199-234 |
| Number of pages | 36 |
| Journal | International Review of Cell and Molecular Biology |
| Volume | 299 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Angiogenesis
- Antiangiogenesis
- Cardiovascular system
- Erythropoietin
- Hypoxia
- Tumor growth
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
- Biochemistry
Cite this
Angiogenic effects of erythropoietin. / Ribatti, Domenico.
In: International Review of Cell and Molecular Biology, Vol. 299, 2012, p. 199-234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiogenic effects of erythropoietin
AU - Ribatti, Domenico
PY - 2012
Y1 - 2012
N2 - Erythropoietin (Epo) is a low-molecular weight glycoprotein hormone stimulator of erythropoiesis synthesized in the fetal liver and in the adult kidney. Moreover, Epo is a pleiotropic cytokine that exerts diverse biological effects in non-hematopoietic tissues, and angiogenesis is indicated as one of its extra-hematopoietic functions. The involvement of Epo in angiogenesis may be considered as subset of its role in improving overall tissue oxygenation and of its anti-apoptotic role. In this context, Epo may be considered as an endogenous stimulator of vessel growth during tumor progression, and inhibition of Epo signaling might be suggested as a new antiangiogenic therapeutic approach. It is conceivable suppose that the effect of Epo is multifactorial, depending on the type of tumor and level of functionality of Epo receptor expression in tumor cells, as well as on other variables, such as hypoxic stress and degree of anemia.
AB - Erythropoietin (Epo) is a low-molecular weight glycoprotein hormone stimulator of erythropoiesis synthesized in the fetal liver and in the adult kidney. Moreover, Epo is a pleiotropic cytokine that exerts diverse biological effects in non-hematopoietic tissues, and angiogenesis is indicated as one of its extra-hematopoietic functions. The involvement of Epo in angiogenesis may be considered as subset of its role in improving overall tissue oxygenation and of its anti-apoptotic role. In this context, Epo may be considered as an endogenous stimulator of vessel growth during tumor progression, and inhibition of Epo signaling might be suggested as a new antiangiogenic therapeutic approach. It is conceivable suppose that the effect of Epo is multifactorial, depending on the type of tumor and level of functionality of Epo receptor expression in tumor cells, as well as on other variables, such as hypoxic stress and degree of anemia.
KW - Angiogenesis
KW - Antiangiogenesis
KW - Cardiovascular system
KW - Erythropoietin
KW - Hypoxia
KW - Tumor growth
UR - http://www.scopus.com/inward/record.url?scp=84865964648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865964648&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-394310-1.00005-9
DO - 10.1016/B978-0-12-394310-1.00005-9
M3 - Article
C2 - 22959304
AN - SCOPUS:84865964648
VL - 299
SP - 199
EP - 234
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
SN - 1937-6448
ER -