Abstract
In this study, we investigated the angiogenic response induced by acellular aortic matrices implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. Results showed that acellular matrices were able to induce a strong angiogenic response comparable to that of fibroblast growth factor 2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta 1 (TGF-β1) were added to the matrices and inhibited by the addition of an anti-FGF-2 or anti-TGF-β1 antibodies. The response may be considered dependent on a direct angiogenic effect exerted by the matrices and in part also by the presence of FGF-2 and TGF-β1 in the acellular matrices.
Original language | English |
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Pages (from-to) | 1303-1307 |
Number of pages | 5 |
Journal | Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology |
Volume | 281 |
Issue number | 2 |
DOIs | |
Publication status | Published - Dec 2004 |
Keywords
- Acellular matrices
- Angiogenesis
- Aorta
- Chorioallantoic membrane
- Fibroblast growth factor 2
- Transforming growth factor beta
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Anatomy