Angiogenic response induced by acellular aortic matrix in vivo

Maria Teresa Conconi; Beatrice Nico; Domenica Mangieri; Mara Tommasini; Rosa Di Liddo; Pier Paolo Parnigotto; Gastone G. Nussdorfer; Domenico Ribatti

doi:10.1002/ar.a.20137

Angiogenic response induced by acellular aortic matrix in vivo

Maria Teresa Conconi, Beatrice Nico, Domenica Mangieri, Mara Tommasini, Rosa Di Liddo, Pier Paolo Parnigotto, Gastone G. Nussdorfer, Domenico Ribatti

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we investigated the angiogenic response induced by acellular aortic matrices implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. Results showed that acellular matrices were able to induce a strong angiogenic response comparable to that of fibroblast growth factor 2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta 1 (TGF-β1) were added to the matrices and inhibited by the addition of an anti-FGF-2 or anti-TGF-β1 antibodies. The response may be considered dependent on a direct angiogenic effect exerted by the matrices and in part also by the presence of FGF-2 and TGF-β1 in the acellular matrices.

Original language	English
Pages (from-to)	1303-1307
Number of pages	5
Journal	Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume	281
Issue number	2
DOIs	https://doi.org/10.1002/ar.a.20137
Publication status	Published - Dec 2004

Keywords

Acellular matrices
Angiogenesis
Aorta
Chorioallantoic membrane
Fibroblast growth factor 2
Transforming growth factor beta

ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
Anatomy

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Angiogenic response induced by acellular aortic matrix in vivo. / Conconi, Maria Teresa; Nico, Beatrice; Mangieri, Domenica; Tommasini, Mara; Di Liddo, Rosa; Parnigotto, Pier Paolo; Nussdorfer, Gastone G.; Ribatti, Domenico.

In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, Vol. 281, No. 2, 12.2004, p. 1303-1307.

Research output: Contribution to journal › Article › peer-review

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abstract = "In this study, we investigated the angiogenic response induced by acellular aortic matrices implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. Results showed that acellular matrices were able to induce a strong angiogenic response comparable to that of fibroblast growth factor 2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta 1 (TGF-β1) were added to the matrices and inhibited by the addition of an anti-FGF-2 or anti-TGF-β1 antibodies. The response may be considered dependent on a direct angiogenic effect exerted by the matrices and in part also by the presence of FGF-2 and TGF-β1 in the acellular matrices.",

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AU - Conconi, Maria Teresa

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AU - Mangieri, Domenica

AU - Tommasini, Mara

AU - Di Liddo, Rosa

AU - Parnigotto, Pier Paolo

AU - Nussdorfer, Gastone G.

AU - Ribatti, Domenico

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KW - Angiogenesis

KW - Aorta

KW - Chorioallantoic membrane

KW - Fibroblast growth factor 2

KW - Transforming growth factor beta

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Angiogenic response induced by acellular aortic matrix in vivo

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Keywords

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