Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane

Domenico Ribatti, Maria Teresa Conconi, Beatrice Nico, Silvia Baiguera, Patrizia Corsi, Pier Paolo Parnigotto, Gastone G. Nussdorfer

Research output: Contribution to journalArticlepeer-review

Abstract

The repair and regeneration of injured tissues and organs depend on the re-establishment of the blood flow needed for cellular infiltration and metabolic support. Among the various materials used in tissue reconstruction, acellular scaffolds have recently been utilized. In this study, we investigated the angiogenic response induced by acellular brain scaffolds implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigations. The results show that acellular brain scaffolds are able to induce a strong angiogenic response, comparable to that of fibroblast growth factor-2 (FGF-2), a well known angiogenic cytokine. The response may be considered dependent on a direct angiogenic effect exerted by the scaffold, because no inflammatory infiltrate was detectable in CAM's mesenchyme beneath the implant. Acellular brain scaffolds might induce the release of endogenous angiogenic factors, such as FGF-2 and vascular endothelial growth factor (VEGF) released from the extracellular matrix of the developing CAM. In addition, the angiogenic response may depend, in part, also on the presence in the acellular matrix of transforming growth factor beta 1 (TGFβ1).

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalBrain Research
Volume989
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • Angiogenesis
  • Brain
  • Chorioallantoic membrane
  • Regeneration
  • Scaffold

ASJC Scopus subject areas

  • Neuroscience(all)

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