Angiogenic response induced by acellular femoral matrix in vivo

Maria Teresa Coconi, Beatrice Nico, Piera Rebuffat, Enrico Crivellato, Pier Paolo Parnigotto, Gastone G. Nussdorfer, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review


We investigated the angiogenic response induced by acellular femoral matrices implanted in vivo on to the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. The results showed that acellular matrices were able to induce a strong angiogenic response, comparable with that of fibroblast growth factor-2 (FGF-2), a well-known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF-2 or transforming growth factor beta-1 (TGF-β1) was added to the matrices and inhibited by the addition of anti-FGF-2 or anti-TGF-β1 antibodies. The response may be considered to be dependent on a direct angiogenic effect exerted by the matrices, and also in part by the presence of FGF-2 and TGF-β1 in the acellular matrices.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of Anatomy
Issue number1
Publication statusPublished - Jul 2005


  • Acellular matrices
  • Angiogenesis
  • Chorioallantoic membrane
  • Femur
  • Fibroblast growth factor-2
  • Transforming growth factor-beta

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy


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