Angiographic demonstration of different pathogenetic mechanisms in patients with spontaneous and exertional angina associated with S-T segment depression

Stefano de Servi, Giuseppe Specchia, Diego Ardissino, Colomba Falcone, Antonio Mussini, Luigi Angoli, Ezio Bramucci, G. Piero Marinoni, Antonello Gavazzi, Piero Bobba

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Three patients complained of spontaneous and exertional chest pain, both associated with S-T segment depression in anterior electrocardiographic leads. In each, coronary spasm was demonstrated on coronary arteriography during a spontaneous attack of pain. Coronary arteriograms taken during exercise-induced angina did not show evidence of spastic obstruction; this suggests that exercise-induced chest pain and S-T segment depression were secondary to the increase in oxygen requirements rather than to a sudden decrease in coronary blood flow. Thus, two pathogenetic mechanisms coexisting in the same patient may cause chest pain associated with subendocardial ischemia.

Original languageEnglish
Pages (from-to)1285-1291
Number of pages7
JournalThe American Journal of Cardiology
Issue number6
Publication statusPublished - 1980


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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