TY - JOUR
T1 - Angiographic evaluation of peripheral arterial occlusive disease and its role as a prognostic determinant for major amputation in diabetic subjects with foot ulcers
AU - Faglia, Ezio
AU - Favales, Fabrizio
AU - Quarantiello, Antonella
AU - Calia, Patrizia
AU - Clelia, Paratore
AU - Brambilla, Giorgio
AU - Rampoldi, Antonio
AU - Morabito, Alberto
PY - 1998
Y1 - 1998
N2 - OBJECTIVE - To evaluate in diabetic patients with foot ulcers the angiographic findings of peripheral occlusive arterial disease and their role as a prognostic determinant for major amputation. RESEARCH DESIGN AND METHODS - From 1993 to 1995, 104 diabetic inpatients with foot ulcers underwent arteriography on the ulcerated limb. Stenoses in the iliac trunk, the superficial femoral artery, the profunda femoral artery, the popliteal artery, the anterior tibial artery, the posterior tibial artery, and the peroneal artery were scored on the basis of vessel lumen reduction: 0 if stenoses involved a reduction in the vessel lumen of 2 for trend = 50.57, P <0.001). No major amputation was carried out in patients with angiographic scores 14. Multivariate analysis indicated a high angiographic score as an independent risk factor for major amputation (odds ratio 2.32, P = 0.001, CI 1.40-3.84). CONCLUSIONS - Angiography permits an exact detection of occlusive arterial disease in subjects with normal results for noninvasive vascular procedures. A score that has a relevant prognostic value for major amputation can be obtained from the evaluation of the extent and diffusion of the stenoses.
AB - OBJECTIVE - To evaluate in diabetic patients with foot ulcers the angiographic findings of peripheral occlusive arterial disease and their role as a prognostic determinant for major amputation. RESEARCH DESIGN AND METHODS - From 1993 to 1995, 104 diabetic inpatients with foot ulcers underwent arteriography on the ulcerated limb. Stenoses in the iliac trunk, the superficial femoral artery, the profunda femoral artery, the popliteal artery, the anterior tibial artery, the posterior tibial artery, and the peroneal artery were scored on the basis of vessel lumen reduction: 0 if stenoses involved a reduction in the vessel lumen of 2 for trend = 50.57, P <0.001). No major amputation was carried out in patients with angiographic scores 14. Multivariate analysis indicated a high angiographic score as an independent risk factor for major amputation (odds ratio 2.32, P = 0.001, CI 1.40-3.84). CONCLUSIONS - Angiography permits an exact detection of occlusive arterial disease in subjects with normal results for noninvasive vascular procedures. A score that has a relevant prognostic value for major amputation can be obtained from the evaluation of the extent and diffusion of the stenoses.
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U2 - 10.2337/diacare.21.4.625
DO - 10.2337/diacare.21.4.625
M3 - Article
C2 - 9571354
AN - SCOPUS:0031944359
VL - 21
SP - 625
EP - 630
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 4
ER -