Angiographic findings of the multicenter randomized study with the sirolimus-eluting Bx velocity balloon-expandable stent (RAVEL): Sirolimus-eluting stents inhibit restenosis irrespective of the vessel size

E. Regar, P. W. Serruys, C. Bode, C. Holubarsch, J. L. Guermonprez, W. Wijns, A. Bartorelli, C. Constantini, M. Degertekin, K. Tanabe, C. Disco, E. Wuelfert, M. C. Morice

Research output: Contribution to journalArticle

Abstract

Background - Restenosis remains the major limitation of coronary catheter-based intervention. In small vessels, the amount of neointimal tissue is disproportionately greater than the vessel caliber, resulting in higher restenosis rates. In the Randomized Study With the Sirolimus-Eluting Bx Velocity Balloon-Expandable Stent (RAVEL) trial, ≈40% of the vessels were small (2.84 mm). At 6-month follow-up, the restenosis rate in the SES group was 0% in all strata (versus 35%, 26%, and 20%, respectively, in the BS group). In-stent late loss was 0.01±0.25 versus 0.80±0.43 mm in stratum I, 0.01±0.38 versus 0.88±0.57 mm in stratum II, and -0.06±0.35 versus 0.74±0.57 mm in stratum III (SES versus BS). In SES, the minimal lumen diameter (MLD) remained unchanged (Δ -0.72 to 0.72 mm) in 97% of the lesions and increased (=late gain, ΔMLD

Original languageEnglish
Pages (from-to)1949-1956
Number of pages8
JournalCirculation
Volume106
Issue number15
DOIs
Publication statusPublished - Oct 8 2002

Keywords

  • Angioplasty
  • Drugs
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Angiographic findings of the multicenter randomized study with the sirolimus-eluting Bx velocity balloon-expandable stent (RAVEL): Sirolimus-eluting stents inhibit restenosis irrespective of the vessel size'. Together they form a unique fingerprint.

  • Cite this

    Regar, E., Serruys, P. W., Bode, C., Holubarsch, C., Guermonprez, J. L., Wijns, W., Bartorelli, A., Constantini, C., Degertekin, M., Tanabe, K., Disco, C., Wuelfert, E., & Morice, M. C. (2002). Angiographic findings of the multicenter randomized study with the sirolimus-eluting Bx velocity balloon-expandable stent (RAVEL): Sirolimus-eluting stents inhibit restenosis irrespective of the vessel size. Circulation, 106(15), 1949-1956. https://doi.org/10.1161/01.CIR.0000034045.36219.12