Angiographic patterns of myocardial reperfusion after primary angioplasty and ventricular remodeling

Giampaolo Niccoli, Nicola Cosentino, Antonella Lombardo, Gregory A. Sgueglia, Cristina Spaziani, Francesco Fracassi, Leonardo Cataneo, Silvia Minelli, Francesco Burzotta, Antonio Maria Leone, Italo Porto, Carlo Trani, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Background: No reflow after primary percutaneous coronary intervention is a dynamic process and its reversibility may affect left ventricular (LV) remodeling. We aimed at assessing in-hospital evolution of angiographic no reflow, predictors of its reversibility, and its impact on LV function at follow-up (FU). Methods: Fifty-three consecutive patients (age, 60±10 years; male sex, 79%) presenting with ST-elevation myocardial infarction and undergoing primary percutaneous coronary intervention within 12 h of symptom onset were enrolled. No reflow was defined as a final thrombolysis in myocardial infarction (TIMI) flow of 2 or final TIMI flow of 3 with myocardial blush grade (MBG) of less than 2. The evolution of angiographic no reflow was assessed by repeat in-hospital coronary angiography. Patients with no reflow found to have an improvement of TIMI and/or MBG leading to a final TIMI 3 and MBG of greater than or equal to 2 were classified as reversible no reflow; the remaining patients were classified as sustained no reflow. Variables predicting the patterns of no reflow, recorded on admission, were assessed among clinical, angiographic and laboratory data. FU echocardiographic data (at 6 months) were compared with those obtained in-hospital according to no reflow evolution. Results: Thirty-six patients (68%) exhibited myocardial reperfusion; 17 patients (32%) showed no reflow. Among these, six patients (age, 58±10 years; male sex, 83%) showed sustained no reflow, whereas 11 patients (age, 55±8 years; male sex, 82%) showed reversible no reflow. Patients with sustained no reflow had longer time to percutaneous coronary intervention (261±80 min) compared with those with myocardial reperfusion (216±94 min) or reversible no reflow (237±76 min; P=0.008 and 0.05, respectively). Moreover, patients with sustained no reflow had a higher peak troponin-T levels (14.5 ng/ml; range, 7.5-20.2 ng/ml) compared with those presenting with myocardial reperfusion (3.9 ng/ml; range, 3.3-9.1 ng/ml) and reversible no reflow (7.7 ng/ml; range, 3.6-29.9 ng/ml; P=0.03 and 0.07, respectively). At multivariate ordinal logistic regression, time pre-PCI retained its statistical significant association with angiographic no reflow evolution (odds ratio=2.54; 95% confidence interval: 1.45-6.53; P=0.04), with troponin T levels showing a borderline statistical significance (odds ratio=3.12; 95% confidence interval: 1.07-6.23; P=0.09). Finally, in patients with sustained no reflow only both end-diastolic and end-systolic volumes significantly increased at FU (P

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalCoronary Artery Disease
Volume22
Issue number7
DOIs
Publication statusPublished - Nov 2011

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Myocardial Reperfusion
Ventricular Remodeling
Angioplasty
Percutaneous Coronary Intervention
Myocardial Infarction
Troponin T
Odds Ratio
Confidence Intervals
Coronary Angiography
Left Ventricular Function
Logistic Models

Keywords

  • left ventricular remodeling
  • myocardial no reflow
  • primary percutaneous coronary intervention
  • ST-elevation myocardial infarction
  • temporal evolution

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Angiographic patterns of myocardial reperfusion after primary angioplasty and ventricular remodeling. / Niccoli, Giampaolo; Cosentino, Nicola; Lombardo, Antonella; Sgueglia, Gregory A.; Spaziani, Cristina; Fracassi, Francesco; Cataneo, Leonardo; Minelli, Silvia; Burzotta, Francesco; Maria Leone, Antonio; Porto, Italo; Trani, Carlo; Crea, Filippo.

In: Coronary Artery Disease, Vol. 22, No. 7, 11.2011, p. 507-514.

Research output: Contribution to journalArticle

Niccoli, G, Cosentino, N, Lombardo, A, Sgueglia, GA, Spaziani, C, Fracassi, F, Cataneo, L, Minelli, S, Burzotta, F, Maria Leone, A, Porto, I, Trani, C & Crea, F 2011, 'Angiographic patterns of myocardial reperfusion after primary angioplasty and ventricular remodeling', Coronary Artery Disease, vol. 22, no. 7, pp. 507-514. https://doi.org/10.1097/MCA.0b013e32834a37ae
Niccoli, Giampaolo ; Cosentino, Nicola ; Lombardo, Antonella ; Sgueglia, Gregory A. ; Spaziani, Cristina ; Fracassi, Francesco ; Cataneo, Leonardo ; Minelli, Silvia ; Burzotta, Francesco ; Maria Leone, Antonio ; Porto, Italo ; Trani, Carlo ; Crea, Filippo. / Angiographic patterns of myocardial reperfusion after primary angioplasty and ventricular remodeling. In: Coronary Artery Disease. 2011 ; Vol. 22, No. 7. pp. 507-514.
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abstract = "Background: No reflow after primary percutaneous coronary intervention is a dynamic process and its reversibility may affect left ventricular (LV) remodeling. We aimed at assessing in-hospital evolution of angiographic no reflow, predictors of its reversibility, and its impact on LV function at follow-up (FU). Methods: Fifty-three consecutive patients (age, 60±10 years; male sex, 79{\%}) presenting with ST-elevation myocardial infarction and undergoing primary percutaneous coronary intervention within 12 h of symptom onset were enrolled. No reflow was defined as a final thrombolysis in myocardial infarction (TIMI) flow of 2 or final TIMI flow of 3 with myocardial blush grade (MBG) of less than 2. The evolution of angiographic no reflow was assessed by repeat in-hospital coronary angiography. Patients with no reflow found to have an improvement of TIMI and/or MBG leading to a final TIMI 3 and MBG of greater than or equal to 2 were classified as reversible no reflow; the remaining patients were classified as sustained no reflow. Variables predicting the patterns of no reflow, recorded on admission, were assessed among clinical, angiographic and laboratory data. FU echocardiographic data (at 6 months) were compared with those obtained in-hospital according to no reflow evolution. Results: Thirty-six patients (68{\%}) exhibited myocardial reperfusion; 17 patients (32{\%}) showed no reflow. Among these, six patients (age, 58±10 years; male sex, 83{\%}) showed sustained no reflow, whereas 11 patients (age, 55±8 years; male sex, 82{\%}) showed reversible no reflow. Patients with sustained no reflow had longer time to percutaneous coronary intervention (261±80 min) compared with those with myocardial reperfusion (216±94 min) or reversible no reflow (237±76 min; P=0.008 and 0.05, respectively). Moreover, patients with sustained no reflow had a higher peak troponin-T levels (14.5 ng/ml; range, 7.5-20.2 ng/ml) compared with those presenting with myocardial reperfusion (3.9 ng/ml; range, 3.3-9.1 ng/ml) and reversible no reflow (7.7 ng/ml; range, 3.6-29.9 ng/ml; P=0.03 and 0.07, respectively). At multivariate ordinal logistic regression, time pre-PCI retained its statistical significant association with angiographic no reflow evolution (odds ratio=2.54; 95{\%} confidence interval: 1.45-6.53; P=0.04), with troponin T levels showing a borderline statistical significance (odds ratio=3.12; 95{\%} confidence interval: 1.07-6.23; P=0.09). Finally, in patients with sustained no reflow only both end-diastolic and end-systolic volumes significantly increased at FU (P",
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T1 - Angiographic patterns of myocardial reperfusion after primary angioplasty and ventricular remodeling

AU - Niccoli, Giampaolo

AU - Cosentino, Nicola

AU - Lombardo, Antonella

AU - Sgueglia, Gregory A.

AU - Spaziani, Cristina

AU - Fracassi, Francesco

AU - Cataneo, Leonardo

AU - Minelli, Silvia

AU - Burzotta, Francesco

AU - Maria Leone, Antonio

AU - Porto, Italo

AU - Trani, Carlo

AU - Crea, Filippo

PY - 2011/11

Y1 - 2011/11

N2 - Background: No reflow after primary percutaneous coronary intervention is a dynamic process and its reversibility may affect left ventricular (LV) remodeling. We aimed at assessing in-hospital evolution of angiographic no reflow, predictors of its reversibility, and its impact on LV function at follow-up (FU). Methods: Fifty-three consecutive patients (age, 60±10 years; male sex, 79%) presenting with ST-elevation myocardial infarction and undergoing primary percutaneous coronary intervention within 12 h of symptom onset were enrolled. No reflow was defined as a final thrombolysis in myocardial infarction (TIMI) flow of 2 or final TIMI flow of 3 with myocardial blush grade (MBG) of less than 2. The evolution of angiographic no reflow was assessed by repeat in-hospital coronary angiography. Patients with no reflow found to have an improvement of TIMI and/or MBG leading to a final TIMI 3 and MBG of greater than or equal to 2 were classified as reversible no reflow; the remaining patients were classified as sustained no reflow. Variables predicting the patterns of no reflow, recorded on admission, were assessed among clinical, angiographic and laboratory data. FU echocardiographic data (at 6 months) were compared with those obtained in-hospital according to no reflow evolution. Results: Thirty-six patients (68%) exhibited myocardial reperfusion; 17 patients (32%) showed no reflow. Among these, six patients (age, 58±10 years; male sex, 83%) showed sustained no reflow, whereas 11 patients (age, 55±8 years; male sex, 82%) showed reversible no reflow. Patients with sustained no reflow had longer time to percutaneous coronary intervention (261±80 min) compared with those with myocardial reperfusion (216±94 min) or reversible no reflow (237±76 min; P=0.008 and 0.05, respectively). Moreover, patients with sustained no reflow had a higher peak troponin-T levels (14.5 ng/ml; range, 7.5-20.2 ng/ml) compared with those presenting with myocardial reperfusion (3.9 ng/ml; range, 3.3-9.1 ng/ml) and reversible no reflow (7.7 ng/ml; range, 3.6-29.9 ng/ml; P=0.03 and 0.07, respectively). At multivariate ordinal logistic regression, time pre-PCI retained its statistical significant association with angiographic no reflow evolution (odds ratio=2.54; 95% confidence interval: 1.45-6.53; P=0.04), with troponin T levels showing a borderline statistical significance (odds ratio=3.12; 95% confidence interval: 1.07-6.23; P=0.09). Finally, in patients with sustained no reflow only both end-diastolic and end-systolic volumes significantly increased at FU (P

AB - Background: No reflow after primary percutaneous coronary intervention is a dynamic process and its reversibility may affect left ventricular (LV) remodeling. We aimed at assessing in-hospital evolution of angiographic no reflow, predictors of its reversibility, and its impact on LV function at follow-up (FU). Methods: Fifty-three consecutive patients (age, 60±10 years; male sex, 79%) presenting with ST-elevation myocardial infarction and undergoing primary percutaneous coronary intervention within 12 h of symptom onset were enrolled. No reflow was defined as a final thrombolysis in myocardial infarction (TIMI) flow of 2 or final TIMI flow of 3 with myocardial blush grade (MBG) of less than 2. The evolution of angiographic no reflow was assessed by repeat in-hospital coronary angiography. Patients with no reflow found to have an improvement of TIMI and/or MBG leading to a final TIMI 3 and MBG of greater than or equal to 2 were classified as reversible no reflow; the remaining patients were classified as sustained no reflow. Variables predicting the patterns of no reflow, recorded on admission, were assessed among clinical, angiographic and laboratory data. FU echocardiographic data (at 6 months) were compared with those obtained in-hospital according to no reflow evolution. Results: Thirty-six patients (68%) exhibited myocardial reperfusion; 17 patients (32%) showed no reflow. Among these, six patients (age, 58±10 years; male sex, 83%) showed sustained no reflow, whereas 11 patients (age, 55±8 years; male sex, 82%) showed reversible no reflow. Patients with sustained no reflow had longer time to percutaneous coronary intervention (261±80 min) compared with those with myocardial reperfusion (216±94 min) or reversible no reflow (237±76 min; P=0.008 and 0.05, respectively). Moreover, patients with sustained no reflow had a higher peak troponin-T levels (14.5 ng/ml; range, 7.5-20.2 ng/ml) compared with those presenting with myocardial reperfusion (3.9 ng/ml; range, 3.3-9.1 ng/ml) and reversible no reflow (7.7 ng/ml; range, 3.6-29.9 ng/ml; P=0.03 and 0.07, respectively). At multivariate ordinal logistic regression, time pre-PCI retained its statistical significant association with angiographic no reflow evolution (odds ratio=2.54; 95% confidence interval: 1.45-6.53; P=0.04), with troponin T levels showing a borderline statistical significance (odds ratio=3.12; 95% confidence interval: 1.07-6.23; P=0.09). Finally, in patients with sustained no reflow only both end-diastolic and end-systolic volumes significantly increased at FU (P

KW - left ventricular remodeling

KW - myocardial no reflow

KW - primary percutaneous coronary intervention

KW - ST-elevation myocardial infarction

KW - temporal evolution

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