Angiopoietin-2 TIEs up macrophages in tumor angiogenesis

Michele De Palma, Luigi Naldini

Research output: Contribution to journalArticlepeer-review

Abstract

Angiopoietin-2 (ANG2), a ligand of the TIE2 receptor, modulates endothelial cell biology and destabilizes blood vessels to facilitate angiogenesis. Recent reports have shown that ANG2 inhibition, for example, by monoclonal antibodies, peptibodies, or CovX-Bodies, may achieve substantial antiangiogenic and antitumor responses in a variety of mouse tumor models, including spontaneous MMTV-PyMT mammary and RIP1-Tag2 pancreatic islet adenocarcinomas. There is also evidence that targeting the ANG2/TIE2 signaling pathway may inhibit the functions of TIE2-expressing macrophages (TEM), a tumor-associated macrophage subset endowed with proangiogenic activity in mouse tumor models. The clinical opportunities afforded by simultaneously targeting the effects of ANG2 on tumor angiogenesis and the proangiogenic activity of TEMs are discussed.

Original languageEnglish
Pages (from-to)5226-5232
Number of pages7
JournalClinical Cancer Research
Volume17
Issue number16
DOIs
Publication statusPublished - Aug 15 2011

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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